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Details

Stereochemistry ABSOLUTE
Molecular Formula C43H78N6O13
Molecular Weight 887.1118
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ROMURTIDE

SMILES

[H][C@](O[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCCCCCC)C(O)=O)C(N)=O)([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O

InChI

InChIKey=IKSJCVFYCIKDTB-GZZWOGMVSA-N
InChI=1S/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-36(54)45-26-21-20-22-33(43(60)61)48-37(55)25-24-32(40(44)57)49-41(58)29(2)46-42(59)30(3)62-39(38(56)35(53)28-51)34(27-50)47-31(4)52/h27,29-30,32-35,38-39,51,53,56H,5-26,28H2,1-4H3,(H2,44,57)(H,45,54)(H,46,59)(H,47,52)(H,48,55)(H,49,58)(H,60,61)/t29-,30+,32+,33-,34-,35+,38+,39+/m0/s1

HIDE SMILES / InChI

Description

Romurtide (Muroctasin) is a non-specific immune stimulant derived from muramyl dipeptide, which is obtained from gram-positive bacterial cell walls. Muroctasin stimulates macrophages, which release interleukin-l, which in turn increases production of colony-stimulating factors; muroctasin also evokes an increased production of neutrophils. It is used in Japan for chemotherapy-induced leukopenia.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Muroctasin
Secondary
Muroctasin
Primary
Muroctasin

PubMed

Sample Use Guides

In Vivo Use Guide
For the treatment of leukopenia and thrombopenia 200 ug of Romurtide (muroctasin) for 6 days post-chemotherapy.
Route of Administration: Intravenous
In Vitro Use Guide
More than 1 ng/ml- of romurtide was needed to induce IL-1b and TNF, in contrast, only 0.1 ng/ml of the compound induced the substantial level of IL-8 in monkey PBMCs .