| Stereochemistry | ACHIRAL |
| Molecular Formula | 2C11H16N2O.CH2O3 |
| Molecular Weight | 446.5399 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(O)=O.COC1=C(C=CC=C1)N2CCNCC2.COC3=C(C=CC=C3)N4CCNCC4
InChI
InChIKey=INQXKLUQTNOTIG-UHFFFAOYSA-N
InChI=1S/2C11H16N2O.CH2O3/c2*1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;2-1(3)4/h2*2-5,12H,6-9H2,1H3;(H2,2,3,4)
1-(2-methoxyphenyl)piperazine is an effective blocker of striatal dopaminergic receptors in rat brain and is apparently the simplest chemical structure known to exert dopaminergic blocking activity. It is exhibited pronounced antihypertensive and weak sympatholytic activities in experimental animals. Blood pressure was also lowered in hypertensive patients and this effect was sometimes accompanied by a strong sedation, and after large repeated doses, by disorientation and stupor. In a filter paper bioassay 1-(2-methoxyphenyl)piperazine demonstrated acaricidal activity. 1-(2-methoxyphenyl)piperazine is a building block of many serotonergic and dopaminergic agents. Some of them have antidepressant activity.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development of novel mixed-ligand oxotechnetium [SNS/S] complexes as potential 5-HT1A receptor imaging agents. | 2001 Mar |
|
| A comparison of solid sampler methods for the determination of hexamethylene-based isocyanates in spray-painting operations. | 2001 Mar-Apr |
|
| 2-H- and 2-acyl-9- [omega-[4-(2-methoxyphenyl)piperazinyl]-alkyl]-1,2,3,4-tetrahydro-beta-carbolines as ligands of 5-HT1A and 5-HT2A receptors. | 2001 Sep-Oct |
|
| Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L. | 2004 |
|
| Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives. | 2004 Dec |
|
| Characterisation of derivatised monomeric and prepolymeric isocyanates by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and structural elucidation by tandem mass spectrometry. | 2005 |
|
| Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats. | 2005 Dec |
|
| Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate. | 2006 Jun |
|
| Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops. | 2006 Jun |
|
| Aniline in hydrolyzed urine and plasma--possible biomarkers for phenylisocyanate exposure. | 2008 Oct |
|
| 3-(1-Adamant-yl)-1-{[4-(2-meth-oxy-phen-yl)piperazin-1-yl]meth-yl}-4-methyl-1H-1,2,4-triazole-5(4H)-thione. | 2010 Jun 23 |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID001002384 | PRIMARY | |||
|
SS19CJ6UK9 | PRIMARY | |||
|
82010-88-6 | PRIMARY | |||
|
279-883-1 | PRIMARY | |||
|
44144684 | PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
