Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H21NO2 |
Molecular Weight | 187.2792 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCC(=O)NO
InChI
InChIKey=QZXOLBPUAUOQFB-UHFFFAOYSA-N
InChI=1S/C10H21NO2/c1-2-3-4-5-6-7-8-9-10(12)11-13/h13H,2-9H2,1H3,(H,11,12)
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/5893181Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/4379485
https://www.ncbi.nlm.nih.gov/pubmed/5893656
https://www.ncbi.nlm.nih.gov/pubmed/5893830
http://www.drugfuture.com/toxic/q47-q489.html
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5893181
Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/4379485
https://www.ncbi.nlm.nih.gov/pubmed/5893656
https://www.ncbi.nlm.nih.gov/pubmed/5893830
http://www.drugfuture.com/toxic/q47-q489.html
Decanohydroxamic acid had almost no antibacterial activity. At 100 γ/ml, the acid showed growth inhibition on all the fungi tested except Monosporium apiospermum 213. The acid was found to have atropine-like, papaverine-like, anti-acetylcholine, and antihistamine actions, and a slight effect on blood (number of erythrocytes, leucocytes, and hemoglobin), but no marked effect was found on other factors. The action of this acid on the circulating system is mainly vasodilation and depression of the total carotid pressure, and no marked changes were produced in heart movement and cardiogram. A very slight irritation was observed as its local action, especially in an emulsified ointment on the skin, but not when the acid was used as a lipophilic ointment. Acute toxicity of the acid was very weak, the 2.5% Tween suspension giving the values of over 1430 mg/kg in mice by subcutaneous and intraperitoneal injection, over 7200 mg/kg in mice by oral administration.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
[Pharmacological studies on decanohydroxamic acid. IV. Subacute oral toxicity on rats]. | 1965 Nov |
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[Pharmacological studies on decanohydroxamic acid. V. Percutaneous absorption, distribution on rats and percutaneous subacute toxicity on rabbits]. | 1965 Nov |
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[Pharmacological studies on decanohydroxamic acid. II. General pharmacological action. (1)]. | 1965 Oct |
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[Pharmacological studies on decanohydroxamic acid. 3. General pharmacological action. (2)]. | 1965 Oct |
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[Pharmacological studies on decanohydroxamic acid. I. Antifungal action]. | 1965 Sep |
|
Induction of hypoxemia in brook trout (Salvelinus fontinalis) following their exposure to n-decanohydroxamic acid, a component of an experimental iron ore flotation agent. | 1978 |
Sample Use Guides
In Vivo Use Guide
Sources: https://chem.nlm.nih.gov/chemidplus/rn/2259-85-0
mouse LD50: 600mg/kg
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5893181
Unknown
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32350
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SK89PC0K0E
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2259-85-0
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DTXSID7046883
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142752
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SUBSTANCE RECORD