U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H21NO2
Molecular Weight 187.2792
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DECANOHYDROXAMIC ACID

SMILES

CCCCCCCCCC(=O)NO

InChI

InChIKey=QZXOLBPUAUOQFB-UHFFFAOYSA-N
InChI=1S/C10H21NO2/c1-2-3-4-5-6-7-8-9-10(12)11-13/h13H,2-9H2,1H3,(H,11,12)

HIDE SMILES / InChI

Description
Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/4379485 https://www.ncbi.nlm.nih.gov/pubmed/5893656 https://www.ncbi.nlm.nih.gov/pubmed/5893830 http://www.drugfuture.com/toxic/q47-q489.html

Decanohydroxamic acid had almost no antibacterial activity. At 100 γ/ml, the acid showed growth inhibition on all the fungi tested except Monosporium apiospermum 213. The acid was found to have atropine-like, papaverine-like, anti-acetylcholine, and antihistamine actions, and a slight effect on blood (number of erythrocytes, leucocytes, and hemoglobin), but no marked effect was found on other factors. The action of this acid on the circulating system is mainly vasodilation and depression of the total carotid pressure, and no marked changes were produced in heart movement and cardiogram. A very slight irritation was observed as its local action, especially in an emulsified ointment on the skin, but not when the acid was used as a lipophilic ointment. Acute toxicity of the acid was very weak, the 2.5% Tween suspension giving the values of over 1430 mg/kg in mice by subcutaneous and intraperitoneal injection, over 7200 mg/kg in mice by oral administration.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Pharmacological studies on decanohydroxamic acid. IV. Subacute oral toxicity on rats].
1965 Nov
[Pharmacological studies on decanohydroxamic acid. V. Percutaneous absorption, distribution on rats and percutaneous subacute toxicity on rabbits].
1965 Nov
[Pharmacological studies on decanohydroxamic acid. 3. General pharmacological action. (2)].
1965 Oct
[Pharmacological studies on decanohydroxamic acid. I. Antifungal action].
1965 Sep
Induction of hypoxemia in brook trout (Salvelinus fontinalis) following their exposure to n-decanohydroxamic acid, a component of an experimental iron ore flotation agent.
1978

Sample Use Guides

mouse LD50: 600mg/kg
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Name Type Language
DECANOHYDROXAMIC ACID
JAN  
Systematic Name English
DECANOHYDROXAMIC ACID [JAN]
Common Name English
N-HYDROXYDECANAMIDE
Systematic Name English
N-DECANOHYDROXAMIC ACID
Common Name English
DECANAMIDE, N-HYDROXY-
Systematic Name English
CAPRINOHYDROXAMIC ACID
Systematic Name English
Code System Code Type Description
CHEBI
32350
Created by admin on Sat Dec 16 02:17:03 GMT 2023 , Edited by admin on Sat Dec 16 02:17:03 GMT 2023
PRIMARY
FDA UNII
SK89PC0K0E
Created by admin on Sat Dec 16 02:17:03 GMT 2023 , Edited by admin on Sat Dec 16 02:17:03 GMT 2023
PRIMARY
CAS
2259-85-0
Created by admin on Sat Dec 16 02:17:03 GMT 2023 , Edited by admin on Sat Dec 16 02:17:03 GMT 2023
PRIMARY
EPA CompTox
DTXSID7046883
Created by admin on Sat Dec 16 02:17:03 GMT 2023 , Edited by admin on Sat Dec 16 02:17:03 GMT 2023
PRIMARY
PUBCHEM
142752
Created by admin on Sat Dec 16 02:17:03 GMT 2023 , Edited by admin on Sat Dec 16 02:17:03 GMT 2023
PRIMARY