Details
Stereochemistry | RACEMIC |
Molecular Formula | C20H24FN3O4.2H2O |
Molecular Weight | 425.4512 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.CNC1CCCN(C1)C2=C(OC)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O
InChI
InChIKey=WEGNYJXOCPJAPS-UHFFFAOYSA-N
InChI=1S/C20H24FN3O4.2H2O/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27;;/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27);2*1H2
DescriptionSources: http://www.tabletwise.com/baloxin-tabletCurator's Comment: description was created based on several sources, including:
https://www.medicineindia.org/pharmacology-for-generic/2923/balofloxacin
http://www.ajptr.com/archive/volume-2/february-2012-issue-1/article-92.html
Sources: http://www.tabletwise.com/baloxin-tablet
Curator's Comment: description was created based on several sources, including:
https://www.medicineindia.org/pharmacology-for-generic/2923/balofloxacin
http://www.ajptr.com/archive/volume-2/february-2012-issue-1/article-92.html
Balofloxacin (Q-35), is an orally active fluoroquinolone antibiotic. It has been developed for the treatment of urinary tract infection. The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae. Side effects of Balofloxacin are: sensitivity to light, abdominal pain, nausea, heartburn, urticarial, irritation when applied locally. Balofloxacin may interact with the following medicines and salts: antacids, non-steroidal anti-inflammatory drug, quinolones, theophylline.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2311224 Sources: http://www.ncbi.nlm.nih.gov/pubmed/8000379 |
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Target ID: CHEMBL1895 Sources: http://www.ncbi.nlm.nih.gov/pubmed/19478540 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | Q-Roxin Approved UseTreatment of uncomplicated urinary tract infections Launch Date2000 |
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Curative | Unknown Approved UseUnknown |
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Curative | Barofloxacin Approved UseBarofloxacin is a quinolone antibiotic, prescribed for the treatment of infective ophthalmitis. |
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Curative | Balofloxacin Approved UseBarofloxacin is a quinolone antibiotic, prescribed for the treatment of skin infections. |
PubMed
Title | Date | PubMed |
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[In vitro anti-MAC activities of new quinolones in focus (2)]. | 1996 Sep |
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History of quinolones and their side effects. | 2001 |
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Aquatic photochemistry of fluoroquinolone antibiotics: kinetics, pathways, and multivariate effects of main water constituents. | 2010 Apr 1 |
Patents
Sample Use Guides
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6918202
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SH1AVB6TVK
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admin on Sat Dec 16 06:16:54 GMT 2023 , Edited by admin on Sat Dec 16 06:16:54 GMT 2023
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151060-21-8
Created by
admin on Sat Dec 16 06:16:54 GMT 2023 , Edited by admin on Sat Dec 16 06:16:54 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD