Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2C2H3O2.Cd.2H2O |
Molecular Weight | 266.53 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Cd++].CC([O-])=O.CC([O-])=O
InChI
InChIKey=AUIZLSZEDUYGDE-UHFFFAOYSA-L
InChI=1S/2C2H4O2.Cd.2H2O/c2*1-2(3)4;;;/h2*1H3,(H,3,4);;2*1H2/q;;+2;;/p-2
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: human serum albumin aggregation Sources: https://www.ncbi.nlm.nih.gov/pubmed/24771482 |
PubMed
Title | Date | PubMed |
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Nerve growth factor-stimulated calcium uptake into PC12 cells: uniqueness of the channel and evidence for phosphorylation. | 1992 Apr |
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Reactive oxygen species may participate in the mutagenicity and mutational spectrum of cadmium in Chinese hamster ovary-K1 cells. | 1996 Dec |
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Identification of genes that are induced after cadmium exposure by suppression subtractive hybridization. | 2003 Sep 30 |
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Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung. | 2004 Aug |
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Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway. | 2004 Nov 1 |
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Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells. | 2005 Aug 1 |
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Effects of cadmium exposure on testis apoptosis in the marine teleost Gobius niger. | 2005 May 15 |
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Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium. | 2006 Jan 1 |
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The in vitro immune modulation by cadmium depends on the way of cell activation. | 2006 May 1 |
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A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. | 2006 May 1 |
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Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells. | 2007 Mar |
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Gene expression profiling in human lung fibroblast following cadmium exposure. | 2008 Mar |
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Biochemical and molecular effects of gestational and lactational coexposure to lead and cadmium on ovarian steroidogenesis are associated with oxidative stress in F1 generation rats. | 2010 Nov-Dec |
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Pre-treatment with N-acetylcysteine upregulates superoxide dismutase 2 and catalase genes in cadmium-induced oxidative stress in the chick omphalocele model. | 2011 Feb |
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Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts. | 2011 Mar |
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Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt. | 2011 May |
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Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells. | 2013 Apr |
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Disturbance of SHH signalling pathway during early embryogenesis in the cadmium-induced omphalocele chick model. | 2013 Feb |
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Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. | 2014 Jan |
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Cadmium induces PC12 cells apoptosis via an extracellular signal-regulated kinase and c-Jun N-terminal kinase-mediated mitochondrial apoptotic pathway. | 2014 May |
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Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases. | 2014 Sep |
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The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. | 2015 Jan |
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Exposure of chick embryos to cadmium changes the extra-embryonic vascular branching pattern and alters expression of VEGF-A and VEGF-R2. | 2015 Nov 15 |
Patents
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DTXSID2033281
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5743-04-4
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SA10IX931V
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6537495
Created by
admin on Sat Dec 16 08:23:04 GMT 2023 , Edited by admin on Sat Dec 16 08:23:04 GMT 2023
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SUBSTANCE RECORD