BERLAFENONE HYDROCHLORIDE

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO2.ClH
Molecular Weight	335.868
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

Cl.CC(C)(C)NCC(O)COC1=C(C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=AHEWKBSXIVYTEN-UHFFFAOYSA-N

InChI=1S/C19H25NO2.ClH/c1-19(2,3)20-13-16(21)14-22-18-12-8-7-11-17(18)15-9-5-4-6-10-15;/h4-12,16,20-21H,13-14H2,1-3H3;1H

HIDE SMILES / InChI

Description

Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent, but development has been discontinued.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunit 76	Blocker 537

PubMed

Show entries

Title	Date	PubMed
Negative inotropic effects of the new class I antiarrhythmic agents berlafenone and alprafenone on electrically stimulated isolated cardiomyocytes.	1992 Mar	1497686

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Patents

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Name

Type

Language

BERLAFENONE HYDROCHLORIDE

Common Name

English

DIPRANOL HYDROCHLORIDE

Common Name

English

2-PROPANOL, 1-((1,1'-BIPHENYL)-2-YLOXY)-3-((1,1-DIMETHYLETHYL)AMINO)-, HYDROCHLORIDE (1:1)

Systematic Name

English

GK-23G

Code

English

BIPRANOL HYDROCHLORIDE

Common Name

English

Showing 1 to 5 of 5 entries

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Code System

Code

Type

Description

EPA CompTox

DTXSID60940478

PRIMARY

CAS

18965-98-5

PRIMARY

PUBCHEM

177034

PRIMARY

FDA UNII

S8QX5YHN93

PRIMARY

Showing 1 to 4 of 4 entries

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SUBSTANCE RECORD


					S8QX5YHN93

BERLAFENONE HYDROCHLORIDE