Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H7NO3 |
| Molecular Weight | 129.114 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCN1C(=O)CCC1=O
InChI
InChIKey=AZVYYSCOCHRFKW-UHFFFAOYSA-N
InChI=1S/C5H7NO3/c7-3-6-4(8)1-2-5(6)9/h7H,1-3H2
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/26740206
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00058337
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/26740206
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00058337
N-hydroxymethylsuccinimide is used for ester prodrugs synthesis and as proallergen in epicutaneous patch test, indicated for use as an aid in the diagnosis of allergic contact dermatitis.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf https://www.ncbi.nlm.nih.gov/pubmed/2600209 DOI: 10.1111/j.1600-0536.1990.tb05134.x |
Diagnostic | TRUE Test Approved UseN-hydroxymethyl succinimide is used as proallergen, which is cleaved into succinimide and formaldehyde when it comes in contact with the transepidermal water on the surface of the skin. |
Sample Use Guides
In Vivo Use Guide
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2f082b68-dc74-418a-9e6f-b3c285b41d44
Curator's Comment: The content of formaldehyde in the proallergen (N-hydroxymethyl succinimide) is 22.1% to 24.1%. The product is formulated to contain 180 mcg/cm2 of formaldehyde.
About 780 ug/cm2
Route of Administration:
Topical
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SUBSTANCE RECORD
