Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C48H73N11O10S.3C2H4O2 |
| Molecular Weight | 1176.382 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)=O.CC(O)=O.CC(O)=O.CS(=O)(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCCCCCCCCN
InChI
InChIKey=SQMYCWHGGFDQSL-ZRJVJLHYSA-N
InChI=1S/C48H73N11O10S.3C2H4O2/c1-70(68,69)27-23-36(51)43(62)55-38(21-22-42(60)61)46(65)59-41(30-35-31-52-32-54-35)48(67)58-40(29-34-18-10-7-11-19-34)47(66)56-37(20-12-14-25-50)45(64)57-39(28-33-16-8-6-9-17-33)44(63)53-26-15-5-3-2-4-13-24-49;3*1-2(3)4/h6-11,16-19,31-32,36-41H,2-5,12-15,20-30,49-51H2,1H3,(H,52,54)(H,53,63)(H,55,62)(H,56,66)(H,57,64)(H,58,67)(H,59,65)(H,60,61);3*1H3,(H,3,4)/t36-,37+,38-,39-,40-,41-;;;/m0.../s1
Ebiratide (Hoe 427) is a peptide analog of corticotrophin (ACTH 4-9). Ebiratide is endocrinologically inert. Ebiratide is highly lipophilic and has prolonged metabolic stability. Ebiratide exerts neurotrophic properties in vivo. It also was proven to have significant effects on acetylcholine metabolism. It has been investigated in the treatment of Alzheimer's disease.
Originator
Approval Year
Sample Use Guides
In an acute trial, three different dosages (60, 300, and 600 micrograms) of the endocrinologically inert but behaviorally active corticotropin 4-9 (ACTH4-9) fragment ebiratide were given to three patients with clinically probable Alzheimer's disease and five patients with a major depressive episode who were psychomotor retarded.
Route of Administration:
Intravenous
The 5-day treatment with ebiratide (10-100 pmol/ml) partially prevented neuronal degeneration that occurred in the cultures in which cells were sparsely plated. Ebiratide (10 pmol/ ml) increased choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities up to 1.5 and 1.2 times the respective control values in the sub-confluent cultures.
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115994-46-2
Created by
admin on Fri Dec 15 16:24:18 GMT 2023 , Edited by admin on Fri Dec 15 16:24:18 GMT 2023
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6918102
Created by
admin on Fri Dec 15 16:24:18 GMT 2023 , Edited by admin on Fri Dec 15 16:24:18 GMT 2023
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S4QA804W04
Created by
admin on Fri Dec 15 16:24:18 GMT 2023 , Edited by admin on Fri Dec 15 16:24:18 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
