Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H42N6O7 |
| Molecular Weight | 610.7012 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC3=CNC4=CC=CC=C34)NC1=O)C(C)C
InChI
InChIKey=VYCMAAOURFJIHD-PJNXIOHISA-N
InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
BQ-123 is a selective endothelin receptor-1 antagonist; it is used as a biochemical tool in the study of endothelin receptor function. BQ-123 was suspected to contribute to the regulation of vascular tone humans. However, a study involving young normotensive subjects did not demonstrate any major role for BQ-123 regulation of vascular tone.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. | 1995 May |
|
| Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. | 2002 Apr |
|
| Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons. | 2003 Aug |
|
| Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. | 2003 Aug |
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| Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. | 2003 Jul |
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| Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. | 2003 May |
|
| Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct. | 2003 May 15 |
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| Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch. | 2005 Apr |
|
| Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation. | 2005 Nov |
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| Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure. | 2005 Sep |
|
| Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. | 2006 Aug |
|
| Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock. | 2007 Apr |
|
| NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. | 2007 Sep 1 |
|
| Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. | 2009 Apr |
|
| Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. | 2011 Nov |
|
| Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes. | 2011 Sep 30 |
|
| BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. | 2015 Feb 1 |
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S2A8YZM151
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DB12054
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443289
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136553-81-6
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DTXSID70929476
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BQ-123
Created by
admin on Fri Dec 15 16:31:12 GMT 2023 , Edited by admin on Fri Dec 15 16:31:12 GMT 2023
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
