DALTROBAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H16ClNO4S
Molecular Weight	353.821
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC=C(CCNS(=O)(=O)C2=CC=C(Cl)C=C2)C=C1

InChI

InChIKey=IULOBWFWYDMECP-UHFFFAOYSA-N

InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2929397 | https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1527-3466.1998.tb00358.x | https://adisinsight.springer.com/drugs/800000129

Daltroban (also known as BM 13505, SKF 96148), a specific thromboxane A2 receptor antagonist, was studied as an antithrombotic agent. The drug was licensed to Smith Kline Beecham, underwent phase III clinical trials in the UK and Germany as an antithrombotic agent but did not enter clinical trials in the USA. Besides, вaltroban was investigated in patients with an ischemic heart disorder. However, the development of daltroban has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thromboxane A2 receptor 19 Target ID: CHEMBL3156 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10091692	Antagonist 2778		37.1 nM [IC50]

PubMed

Title	Date	PubMed
Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats.	1989 Apr	2929397
Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets.	1992 Jul	1434130
Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022.	1997 Jun 11	9218700

Sample Use Guides

In Vivo Use Guide

10 healthy volunteers were given 400 mg p.o., the terminal half-life was 7 h,

Route of Administration: Oral

Name

Type

Language

DALTROBAN

Official Name

English

BENZENEACETIC ACID, 4-(2-(((4-CHLOROPHENYL)SULFONYL)AMINO)ETHYL)-

Systematic Name

English

DALTROBAN [MI]

Common Name

English

BM-13505

Code

English

DALTROBAN [USAN]

Common Name

English

BM13505

Code

English

SKF96148

Code

English

(P-(2-(P-CHLOROBENZENESULFONAMIDO)ETHYL)PHENYL)ACETIC ACID

Systematic Name

English

daltroban [INN]

Common Name

English

SKF-96148

Code

English

Code System Code Type Description

NCI_THESAURUS

C169873