Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8O5.2Na |
| Molecular Weight | 230.1257 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-]C(=O)[C@H]1[C@@H]2CC[C@@H](O2)[C@H]1C([O-])=O
InChI
InChIKey=XRHVZWWRFMCBAZ-PXYBLNDHSA-L
InChI=1S/C8H10O5.2Na/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12;;/h3-6H,1-2H2,(H,9,10)(H,11,12);;/q;2*+1/p-2/t3-,4+,5-,6+;;
Endothal (also known as Endothall), a herbicide for terrestrial and aquatic plants, is a potent, selective protein phosphatase 2A (PP2A) inhibitor. It also inhibits protein phosphatase 1 (PP1). Endothall is considered safe in drinking water, but in case of consumption for a long period, it can cause stomach or intestinal problems.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P67775 Gene ID: 5515.0 Gene Symbol: PPP2CA Target Organism: Homo sapiens (Human) |
90.0 nM [IC50] | ||
Target ID: P62136 Gene ID: 5499.0 Gene Symbol: PPP1CA Target Organism: Homo sapiens (Human) |
5.0 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines. | 2003 Feb |
|
| Sites of protein kinase A activation of the human ClC-2 Cl(-) channel. | 2004 May 21 |
|
| Retinoic acid induced repression of AP-1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells. | 2005 Sep 1 |
|
| The 1:1 cocrystal of rac-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid and 2-amino-benzothia-zole. | 2008 Jul 9 |
|
| 1,3-Benzothia-zol-2-amine. | 2009 Jul 18 |
|
| Poly[bis-(1H-imidazole)(μ(3)-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato)cadmium(II)]. | 2009 Jun 17 |
|
| Benzothia-zol-2-amine-3-meth-oxy-carbonyl-7-oxabicyclo-[2.2.1]hept-5-ene-2-carb-oxy-lic acid (1/1). | 2010 Dec 18 |
Sample Use Guides
The effects of glutamate, 17β-estradiol, and various specific inhibitors of protein phosphatases on the activity of PP2A and calcineurin in primary cortical neurons were measured by simultaneously treating with glutamate, okadaic acid, 17β-estradiol, PPI2, endothall, and/or cyclosporin A. Glutamate, okadaic acid, and 9 μM endothall treatment caused decreases in PP2A activity, whereas PPI2 and cyclosporine A had no effect. The decreased PP2A activity mediated by glutamate was attenuated in the presence 17β-estradiol; however, 17β-estradiol was unable to block the okadaic acid or endothall-mediated decrease in PP2A activity. In fact, the presence of okadaic acid or endothall prevented the 17β-estradiol-mediated attenuation of the decreased PP2A activity caused by glutamate.
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
38903
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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44318676
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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204-959-8
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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DTXSID1041899
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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RZ5H9H2D2J
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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endothal-disodium
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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129-67-9
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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PRIMARY | |||
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33054-59-0
Created by
admin on Sat Dec 16 02:52:53 GMT 2023 , Edited by admin on Sat Dec 16 02:52:53 GMT 2023
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ALTERNATIVE |
SUBSTANCE RECORD
