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Details

Stereochemistry ACHIRAL
Molecular Formula C19H17NO5
Molecular Weight 339.342
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MOFEZOLAC

SMILES

COC1=CC=C(C=C1)C2=NOC(CC(O)=O)=C2C3=CC=C(OC)C=C3

InChI

InChIKey=DJEIHHYCDCTAAH-UHFFFAOYSA-N
InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)

HIDE SMILES / InChI

Description

Mofezolac is an NSAID ) (non-steroidal anti-inflammatory drug), which acts via the cyclooxygenase enzyme, preferentially to COX-1. It also has potent inhibitory activity on the algesic responses induced by the mechanical stimulus of the inflamed tissue. It was introduced for the treatment of postoperative and posttraumatic pain, acute upper respiratory tract pain, osteoarthritis, and lumbago. It marketed only in Japan by Yoshitomi Pharmaceutical Ltd. Japan, was approved in July 1994.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Disopain
Primary
Disopain

PubMed

Sample Use Guides

In Vivo Use Guide
General dosage regimen (for adults): Take 1 tablet (75mg of the active ingredient) at a time three times a day after meals.
Route of Administration: Oral
In Vitro Use Guide
Mofezolac affected neither the number of TRAP-positive multinucleated cells nor the extent of lacunar resorption pits.