ONO-4817

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28N2O6
Molecular Weight	416.4675
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCOCOC[C@H](C[C@H](C)C(=O)NO)NC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1

InChI

InChIKey=HDWWQELUBWGQGA-WMZOPIPTSA-N

InChI=1S/C22H28N2O6/c1-3-28-15-29-14-18(13-16(2)21(25)24-27)23-22(26)17-9-11-20(12-10-17)30-19-7-5-4-6-8-19/h4-12,16,18,27H,3,13-15H2,1-2H3,(H,23,26)(H,24,25)/t16-,18-/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
Matrix metalloproteinase-2 13	Inhibitor 8,297	0.72 nM [Ki]
Matrix metalloproteinase 8 6	Inhibitor 8,297	1.1 nM [Ki]
Matrix metalloproteinase 9 20	Inhibitor 8,297	2.1 nM [Ki]
Macrophage metalloelastase 1	Inhibitor 8,297	0.45 nM [Ki]
Matrix metalloproteinase 13 8	Inhibitor 8,297	1.1 nM [Ki]

PubMed

PubMed

Show entries

Title	Date	PubMed
Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters.	2007 Oct 15	17643409

Showing 1 to 1 of 1 entries

Previous1Next

Show entries

Name

Type

Language

ONO-4817

Code

English

N-((1S,3S)-1-((ETHOXYMETHOXY)METHYL)-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL)-4-PHENOXYBENZAMIDE

Systematic Name

English

(-)-ONO-4817

Common Name

English

BENZAMIDE, N-((1S,3S)-1-((ETHOXYMETHOXY)METHYL)-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL)-4-PHENOXY-

Systematic Name

English

ONO4817

Code

English

Showing 1 to 5 of 5 entries

Previous1Next

Show entries

Code System

Code

Type

Description

CAS

223472-31-9

PRIMARY

FDA UNII

RU48RF5PFC

PRIMARY

PUBCHEM

9888141

PRIMARY

Showing 1 to 3 of 3 entries

Previous1Next

ACTIVE MOIETY


					RU48RF5PFC

ONO-4817