AGMATINE SULFATE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H14N4.H2O4S
Molecular Weight	228.27
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.NCCCCNC(N)=N

InChI

InChIKey=PTAYFGHRDOMJGC-UHFFFAOYSA-N

InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Nitric-oxide synthase, brain 24 Target ID: CHEMBL3048 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8645212	Inhibitor 8297	660.0 µM [Ki]
Nitric oxide synthase, inducible 50 Target ID: CHEMBL3464 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8645212	Inhibitor 8297	220.0 µM [Ki]
Nitric-oxide synthase, endothelial 19 Target ID: CHEMBL4802 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8645212	Inhibitor 8297	7.5 mM [Ki]

PubMed

Title	Date	PubMed
Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase.	2001 Aug	11498506
Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N(1)-agmatine and synthetic analogues.	2001 Aug 30	11520203
Isolation and properties of arginase from a shade plant, ginseng (Panax ginseng C.A. Meyer) roots.	2001 Dec	11730864
Biogenic amine production by Lactobacillus.	2001 Feb	11168717
[The content of biogenic amines in canned fish from the Turkish market].	2001 Jul-Aug	11505795
[Imidazoline receptors-normal and pathological factors].	2001 Jul-Sep	12092170
Growth and metabolic activity of Shewanella putrefaciens maintained under different CO2 and O2 concentrations.	2001 Mar 20	11294349
Agmatine produces antinociception in tonic pain in mice.	2001 May-Jun	11420073
Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei.	2001 Oct	11573976
Effects of central imidazolinergic and alpha2-adrenergic activation on water intake.	2001 Sep	11514843
Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats.	2002 Apr	11910050
Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues.	2002 Aug 23	12137915
Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct.	2002 Dec	12427134
Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N.	2002 Dec	12388162
Odor-stimulated glutamatergic neurotransmission in the zebrafish olfactory bulb.	2002 Dec 16	12442320
Effect of agmatine on intracellular free calcium concentration in isolated rat ventricular myocytes.	2002 Dec 25	12506317
Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.	2002 Feb	11834614
Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors.	2002 Feb	11738482
[The arginine paradox].	2002 Jan	11862757
Exposure of rat isolated stomach and rats in vivo to [(14)C]agmatine: accumulation in the stomach wall and distribution in various tissues.	2002 Jun	12165069
Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis.	2002 Jun 28	11980912
Behavior and characteristics of amine derivatives obtained with o-phthaldialdehyde/3-mercaptopropionic acid and with o-phthaldialdehyde/N-acetyl-L-cysteine reagents.	2002 Mar 8	11999740
I(2)-imidazoline binding site affinity of a structurally different type of ligands.	2002 May	11886814
I. Arginine.	2002 Nov	12481980
The metabolic basis of arginine nutrition and pharmacotherapy.	2002 Nov	12481979
Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling.	2002 Nov	12423350
Agmatine facilitates memory of an inhibitory avoidance task in adult rats.	2002 Sep	12431430
Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion.	2002 Sep-Oct	12217050
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine.	2003 Feb	12543244
Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).	2003 Feb	12538837
Agmatine modulates the in vivo biosynthesis and interconversion of polyamines and cell proliferation.	2003 Jan 20	12527112

Patents

Name

Type

Language

AGMATINE SULFATE

Systematic Name

English

Agmatine sulfate [WHO-DD]

Common Name

English

NIH-11035

Code

English

GUANIDINE, N-(4-AMINOBUTYL)-, SULFATE (1:1)

Systematic Name

English

AGMATINE SULFATE [MI]

Common Name

English

Classification Tree Code System Code

DSLD

402 (Number of products:193)