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Details

Stereochemistry MIXED
Molecular Formula C22H28NO3
Molecular Weight 354.4626
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of PIPENZOLATE

SMILES

CC[N+]1(C)CCCC(C1)OC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=WPUKUEMZZRVAKZ-UHFFFAOYSA-N
InChI=1S/C22H28NO3/c1-3-23(2)16-10-15-20(17-23)26-21(24)22(25,18-11-6-4-7-12-18)19-13-8-5-9-14-19/h4-9,11-14,20,25H,3,10,15-17H2,1-2H3/q+1

HIDE SMILES / InChI

Description

Pipenzolate bromide (JB-323), an anticholinergic agent, which binds to muscarinic acetylcholine receptors as an antagonist. Pipenzolate bromide was studied as an antispasmodic agent, and to treat peptic ulcer.

Approval Year

1955
116

Targets

Primary TargetPharmacologyConditionPotency
Muscarinic acetylcholine receptor
160
Antagonist
2,778

Conditions

ConditionModalityTargetsHighest PhaseProduct
Spasms
4
 Primary
Not Provided
504
Unknown
Peptic ulcer
72
 Palliative
Approved
8,429
SINSPASMON

Overview

CYP3A4CYP2C9CYP2D6hERG
inducer
23

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Tox targets

Sourcing

PubMed

Patents

EP1273301A2
4

Sample Use Guides

In Vivo Use Guide
for dog: orally active antispasmodic agent with an atropine-like action
Route of Administration: Oral
In Vitro Use Guide
Unknown
ACTIVE MOIETY
Structure of PIPENZOLATE
NIH
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