| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.6997 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
InChI
InChIKey=PGOYMURMZNDHNS-MYPRUECHSA-N
InChI=1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
Hederagenin is a triterpenoid saponin. It can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB. Hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antilipid peroxidation, antiplatelet aggregation, liver protection, antidepression, anti-inflammation.
CNS Activity
Approval Year
PubMed
Patents
Sample Use Guides
Hederagenin, dissolved in 40% polyethylene glycol,
was administered orally to mice at doses of 5 or 30 mg/kg/day for four
consecutive days.
Route of Administration:
Oral
SUBSTANCE RECORD
