Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H30N2O2.C7H8O3S |
| Molecular Weight | 526.687 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(O)(=O)=O.CC2(C)C(C(=O)C3=CN(CCN4CCOCC4)C5=C3C=CC=C5)C2(C)C
InChI
InChIKey=PJYFREAJNFLEMS-UHFFFAOYSA-N
InChI=1S/C22H30N2O2.C7H8O3S/c1-21(2)20(22(21,3)4)19(25)17-15-24(18-8-6-5-7-16(17)18)10-9-23-11-13-26-14-12-23;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,15,20H,9-14H2,1-4H3;2-5H,1H3,(H,8,9,10)
A-796260 is a compound that acts as a potent and selective cannabinoid CB2 receptor agonist. The analgesic effects of A-796260 on activity-induced pain behavior were evaluated in a rat model, the results demonstrated that A-796260 may be a useful new pharmacological compound for further studying CB2 receptor pharmacology and for evaluating its role in the modulation of pain.
Originator
Approval Year
Sample Use Guides
Neuropathic pain model in rats: The analgesic effects of A-796260 on activity-induced pain behaviour were evaluated in a rat model of sodium monoiodoacetate (MIA)-induced osteoarthritic (OA) joint pain, observed 20 days following the i.a. injection of MIA. A-796260 demonstrated dose-related (3.5-35 mg/kg) reversal of activity-induced pain behaviour in osteoarthritic (OA) rats with effects comparable to celecoxib (38 mg kg−1 i.p.), a clinically relevant analgesic for OA pain.
Route of Administration:
Intraperitoneal
The receptor-binding potencies of A-796260 was determined in [3H]-CP 55,940 competition binding assays performed with membrane preparations generated from recombinant cell lines expressing the human CB1, human CB2, rat CB1 or rat CB2 receptors. A-796260 exhibited high binding potencies at both human and rat CB2 receptors with Ki values of 4.37 and 13.0 nM, respectively
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RNP93O79DW
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11584524
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895155-27-8
Created by
admin on Mon Mar 31 22:10:27 GMT 2025 , Edited by admin on Mon Mar 31 22:10:27 GMT 2025
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ACTIVE MOIETY
SUBSTANCE RECORD
