Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H12ClN3O3 |
| Molecular Weight | 329.738 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1N=C(C2=CC=CC=C2Cl)C3=CC(=CC=C3NC1=O)[N+]([O-])=O
InChI
InChIKey=LMUVYJCAFWGNSY-VIFPVBQESA-N
InChI=1S/C16H12ClN3O3/c1-9-16(21)19-14-7-6-10(20(22)23)8-12(14)15(18-9)11-4-2-3-5-13(11)17/h2-9H,1H3,(H,19,21)/t9-/m0/s1
Meclonazepam (Ro11-3128 or 3-methylclonazepam) is a benzodiazepine derivative. It exerts anxiolytic activity. Meclonazepam demonstrated anti-schistosomal action, it causes spastic paralysis, calcium influx and tegumental disruption in the parasites. Contracturant effect of meclonazepam is not a result of its binding to the worm benzodiazepine binding sites.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The anti-schistosomal drug praziquantel is an adenosine antagonist. | 2007 Aug |
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| Meclonazepam analogues as potential new antihelmintic agents. | 2008 Apr 1 |
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| Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes. | 2008 Jan |
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| Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death. | 2008 Jul |
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| The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors. | 2009 Mar 15 |
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| Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. | 2010 Aug 10 |
Patents
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WIKIPEDIA |
Designer-drugs-Meclonazepam
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NCI_THESAURUS |
C1012
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4912
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C83911
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DTXSID10207366
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SUB08680MIG
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CHEMBL1908326
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100000081758
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RN43209SMA
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58662-84-3
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3033985
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C020602
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MECLONAZEPAM
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ACTIVE MOIETY
METABOLITE (PARENT)
