Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 12MoO3.H2O.H3O4P |
| Molecular Weight | 1843.27 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O
InChI
InChIKey=PDDXOPNEMCREGN-UHFFFAOYSA-N
InChI=1S/12Mo.H3O4P.H2O.36O/c;;;;;;;;;;;;1-5(2,3)4;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h;;;;;;;;;;;;(H3,1,2,3,4);1H2;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;
Molybdenum trioxide (MoO3) is used primarily as an additive to steel and corrosion-resistant alloys. It is also used as a chemical intermediate for molybdenum products; an industrial catalyst; a pigment; a crop nutrient; components of glass, ceramics, and enamels; a flame retardant for polyester and polyvinyl chloride resins; and a reagent in chemical analyses. Molybdenum trioxide was nominated by the NCI for toxicity and carcinogenicity studies as a representative inorganic molybdenum compound. In addition some studies were done, showing the potential utility of MoO3 for treating metastatic cancer cells, which might enable advancements in cancer therapy.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals. | 1997 Feb |
|
| In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. | 2005 Dec |
|
| Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide. | 2017 May |
Patents
Sample Use Guides
toxicity in rats: molybdenum trioxide by inhalation at concentrations of 0, 10, 30, or 100 mg/m(3). Rats were exposed for 6 hours per day, 5 days per week, for 106 weeks.
toxicity in mice: molybdenum trioxide by inhalation at concentrations of 0, 1, 3, 10, 30, or 100 mg/m(3) for 6.5 hours per day, 5 days per week, for 13 weeks
Route of Administration:
Respiratory
It was investigated the cytotoxicity of molybdenum trioxide (MoO3) nanoplates toward invasive breast cancer iMCF-7 cells by analyzing morphological changes and performing Western blot and flow cytometry analyses. It was discovered, that MoO3 exposure induced apoptosis and generated reactive oxygen species (ROS) in iMCF-7 cells.
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SUBSTANCE RECORD
