HYPERFORIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H52O4
Molecular Weight	536.785
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C(=O)[C@]12C(=O)[C@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C(=O)C(CC=C(C)C)=C2O

InChI

InChIKey=IWBJJCOKGLUQIZ-HQKKAZOISA-N

InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.	2003 Nov 15	14633740
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.	2004 Feb	14600250
MDR- and CYP3A4-mediated drug-herbal interactions.	2006 Mar 27	16442130
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.	2007 Dec	17666455
Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists.	2011 Jun 23	21561094
Improved assays for xenosensor activation based on reverse transfection.	2015 Oct	26187274

Patents

Name

Type

Language

HYPERFORIN

Common Name

English

HYPERFORIN (CONSTITUENT OF ST. JOHN'S WORT) [DSC]

Common Name

English

Hyperforin [WHO-DD]

Common Name

English

BICYCLO(3.3.1)NON-3-ENE-2,9-DIONE, 4-HYDROXY-6-METHYL-1,3,7-TRIS(3-METHYL-2-BUTEN-1-YL)-5-(2-METHYL-1-OXOPROPYL)-6-(4-METHYL-3-PENTEN-1-YL)-, (1R,5S,6R,7S)-

Systematic Name

English

HYPERFORIN [HSDB]

Common Name

English

(+)-HYPERFORIN

Common Name

English

HYPERFORIN [MI]

Common Name

English

Classification Tree Code System Code

DSLD

1122 (Number of products:1)