SYMCLOSENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3Cl3N3O3
Molecular Weight	232.409
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O

InChI

InChIKey=YRIZYWQGELRKNT-UHFFFAOYSA-N

InChI=1S/C3Cl3N3O3/c4-7-1(10)8(5)3(12)9(6)2(7)11

HIDE SMILES / InChI

Description
Sources: DOI: 10.1002/047084289X.rt209
Curator's Comment: description was created based on several sources, including http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391200028H.pdf

Trichloroisocyanuric acid (1,3,5-trichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-tri-one or TCCA) is an N-halo compound which has been known since 1902. It has been used primarily as a disinfectant in swimming pools and water treatment as bleaching agent and bactericide. Recently, TCCA has become attractive candidate as a homogeneous catalyst in organic transformations due to its lack of volatility, commercial availability, low cost and ease of handling. And is also used as a bleaching agent in the textile industry

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
A very mild and chemoselective oxidation of alcohols to carbonyl compounds.	2001 Sep 20	11554838
Flow injection chemiluminescence determination of hydrazine by oxidation with chlorinated isocyanurates.	2002 Oct 16	18968808
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.	2003 Feb	12589508
Trichloroisocyanuric/TEMPO oxidation of alcohols under mild conditions: a close investigation.	2003 Jun 13	12790622
A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid.	2003 Nov 7	14649825
Comparison of the disinfection efficacy of chlorine-based products for inactivation of viral indicators and pathogenic bacteria in produce wash water.	2003 Sep	12909560
Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.	2004 Jun	15178311
Effects of selected biocides used in the disinfection of cooling towers on toxicity and bioaccumulation in Artemia larvae.	2005 Dec	16445096
Flow-injection potentiometric determination of triiodide by plasticized poly(vinyl chloride) membrane electrodes and its application to the determination of chlorine-containing disinfectants.	2005 Mar 15	18969930
N,N-dichlorotaurine: chemical and bactericidal properties.	2005 Oct	16211659
[Sodium dichlorinated isocyanuric acid and trichloroisocyanuric acid for removing cells of Phaeochystis globosa].	2006 May	16850840
Synthesis of paromomycin derivatives modified at C(5'') to selectively target bacterial rRNA.	2007 Feb 26	17049499
Response of the freshwater Alga chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin.	2008 Jan	18092852
Cytotoxic and genotoxic effect in RTG-2 cell line exposed to selected biocides used in the disinfection of cooling towers.	2008 May	18274895
Impregnated silica nanoparticles for the reactive removal of sulphur mustard from solutions.	2009 Jan 30	18513865
Iridium/monodentate phosphoramidite catalyzed asymmetric hydrogenation of N-aryl imines.	2009 Jun 24	19530724
Characterization of the products formed by the reaction of trichlorocyanuric acid with 2-propanol.	2009 Nov	19818110
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.	2010 Feb 3	20128903

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

DNA damage has been evaluated on RTG-2 cultures by means of an in vitro assay based on the ability of PicoGreen fluorochrome to interact preferentially with dsDNA, and the results indicated that trichloroisocyanuric acid (Symclosene) induced DNA strand breaks at concentrations above 1.2 mg/l, equivalent to 1/50-EC(50(48))

Name

Type

Language

SYMCLOSENE

Official Name

English

SYMCLOSENE [USAN]

Common Name

English

TRICHLOROISOCYANURIC ACID [MI]

Common Name

English

NSC-405124

Code

English

symclosene [INN]

Common Name

English

TRICHLOROISOCYANURIC ACID

Systematic Name

English

1,3,5-TRICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE

Systematic Name

English

1,3,5-TRIAZINE, 2,4,6(1H,3H,5H)-TRIONE, 1,3,5-TRICHLORO-

Common Name

English

SYMCLOSENE [HSDB]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81405