SYMCLOSENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3Cl3N3O3
Molecular Weight	232.409
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O

InChI

InChIKey=YRIZYWQGELRKNT-UHFFFAOYSA-N

InChI=1S/C3Cl3N3O3/c4-7-1(10)8(5)3(12)9(6)2(7)11

HIDE SMILES / InChI

Description
Sources: DOI: 10.1002/047084289X.rt209
Curator's Comment: description was created based on several sources, including http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391200028H.pdf

Trichloroisocyanuric acid (1,3,5-trichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-tri-one or TCCA) is an N-halo compound which has been known since 1902. It has been used primarily as a disinfectant in swimming pools and water treatment as bleaching agent and bactericide. Recently, TCCA has become attractive candidate as a homogeneous catalyst in organic transformations due to its lack of volatility, commercial availability, low cost and ease of handling. And is also used as a bleaching agent in the textile industry

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.	2010-02-03	20128903
Characterization of the products formed by the reaction of trichlorocyanuric acid with 2-propanol.	2009-11	19818110
Iridium/monodentate phosphoramidite catalyzed asymmetric hydrogenation of N-aryl imines.	2009-06-24	19530724
Impregnated silica nanoparticles for the reactive removal of sulphur mustard from solutions.	2009-01-30	18513865
Cytotoxic and genotoxic effect in RTG-2 cell line exposed to selected biocides used in the disinfection of cooling towers.	2008-05	18274895
Response of the freshwater Alga chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin.	2008-01	18092852
Synthesis of paromomycin derivatives modified at C(5'') to selectively target bacterial rRNA.	2007-02-26	17049499
[Sodium dichlorinated isocyanuric acid and trichloroisocyanuric acid for removing cells of Phaeochystis globosa].	2006-05	16850840
Effects of selected biocides used in the disinfection of cooling towers on toxicity and bioaccumulation in Artemia larvae.	2005-12	16445096
N,N-dichlorotaurine: chemical and bactericidal properties.	2005-10	16211659
Flow-injection potentiometric determination of triiodide by plasticized poly(vinyl chloride) membrane electrodes and its application to the determination of chlorine-containing disinfectants.	2005-03-15	18969930
Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.	2004-06	15178311
A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid.	2003-11-07	14649825
Comparison of the disinfection efficacy of chlorine-based products for inactivation of viral indicators and pathogenic bacteria in produce wash water.	2003-09	12909560
Trichloroisocyanuric/TEMPO oxidation of alcohols under mild conditions: a close investigation.	2003-06-13	12790622
Flow-injection chemiluminescence determination of chlorinated isocyanuric acids.	2003-02	12589508
Flow injection chemiluminescence determination of hydrazine by oxidation with chlorinated isocyanurates.	2002-10-16	18968808
A very mild and chemoselective oxidation of alcohols to carbonyl compounds.	2001-09-20	11554838

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

DNA damage has been evaluated on RTG-2 cultures by means of an in vitro assay based on the ability of PicoGreen fluorochrome to interact preferentially with dsDNA, and the results indicated that trichloroisocyanuric acid (Symclosene) induced DNA strand breaks at concentrations above 1.2 mg/l, equivalent to 1/50-EC(50(48))

Name

Type

Language

SYMCLOSENE

Official Name

English

TRICHLOROISOCYANURIC ACID

Preferred Name

English

SYMCLOSENE [USAN]

Common Name

English

TRICHLOROISOCYANURIC ACID [MI]

Common Name

English

NSC-405124

Code

English

symclosene [INN]

Common Name

English

1,3,5-TRICHLORO-S-TRIAZINE-2,4,6(1H,3H,5H)-TRIONE

Systematic Name

English

1,3,5-TRIAZINE, 2,4,6(1H,3H,5H)-TRIONE, 1,3,5-TRICHLORO-

Common Name

English

SYMCLOSENE [HSDB]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

81405