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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H11I3N2O4.C7H17NO5
Molecular Weight 823.1537
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METRIZOATE MEGLUMINE

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CN(C(C)=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I

InChI

InChIKey=TXKOGNLDVKUFSI-WZTVWXICSA-N
InChI=1S/C12H11I3N2O4.C7H17NO5/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-3H3,(H,16,18)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Description

Metrizoic acid is a diagnostic radiopaque that usually occurs as the sodium salt. The mechanism of action of metrizoic acid is as a X-Ray Contrast Activity.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ISOPAQUE 280

Cmax

ValueDoseCo-administeredAnalytePopulation
300 μg/mL
2310 mg single, intravenous
METRIZOIC ACID serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
250 μg × h/mL
2310 mg single, intravenous
METRIZOIC ACID serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
75.1 min
2310 mg single, intravenous
METRIZOIC ACID serum
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
100%
2310 mg single, intravenous
METRIZOIC ACID serum
Homo sapiens

PubMed

Sample Use Guides

In Vivo Use Guide
0.35 mg/ml; 140.1 mg/ml; 461.8 mg/ml
Route of Administration: Intravascular
In Vitro Use Guide
Unknown