Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C74H100ClN15O14.C2H4O2 |
| Molecular Weight | 1519.183 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC2=CC=CN=C2)NC(=O)[C@@H](CC3=CC=C(Cl)C=C3)NC(=O)[C@@H](CC4=CC=C5C=CC=CC5=C4)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N6CCC[C@H]6C(=O)N[C@H](C)C(N)=O
InChI
InChIKey=RHXRCUIAKDCELH-DBHPVPIESA-N
InChI=1S/C74H100ClN15O14.C2H4O2/c1-43(2)35-57(66(96)84-56(19-10-11-32-79-44(3)4)73(103)90-34-14-20-63(90)72(102)81-45(5)64(76)94)85-65(95)55(18-9-12-33-80-74(77)104)83-68(98)59(38-48-24-29-54(93)30-25-48)88-71(101)62(42-91)89-70(100)61(40-50-15-13-31-78-41-50)87-69(99)60(37-47-22-27-53(75)28-23-47)86-67(97)58(82-46(6)92)39-49-21-26-51-16-7-8-17-52(51)36-49;1-2(3)4/h7-8,13,15-17,21-31,36,41,43-45,55-63,79,91,93H,9-12,14,18-20,32-35,37-40,42H2,1-6H3,(H2,76,94)(H,81,102)(H,82,92)(H,83,98)(H,84,96)(H,85,95)(H,86,97)(H,87,99)(H,88,101)(H,89,100)(H3,77,80,104);1H3,(H,3,4)/t45-,55-,56+,57+,58-,59+,60-,61-,62+,63+;/m1./s1
Teverelix is a polypeptide gonadotropin-releasing hormone (GnRH) antagonist which was being developed by Ardana Bioscience for the treatment of prostate cancer and benign prostatic hyperplasia. Compared with other GnRH antagonists, Teverelix is characterized by relatively good water solubility, little in vitro aggregation, and low histamine-releasing potency, with a dose that produces the halfmaximal response. In preclinical studies, Teverelix has been shown to exert antiovulatory activity. In phase I clinical trials Teverelix shows pronounced luteinizing hormone and testosterone suppressive effects after single subcutaneous doses in healthy men.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pituitary and gonadal endocrine effects and pharmacokinetics of the novel luteinizing hormone-releasing hormone antagonist teverelix in healthy men--a first-dose-in-humans study. | 2000-06 |
|
| Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. | 1997-08-15 |
Patents
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Common Name | English | ||
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Preferred Name | English |
| Code System | Code | Type | Description | ||
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RGS9XB9YPC
Created by
admin on Wed Apr 02 20:52:39 GMT 2025 , Edited by admin on Wed Apr 02 20:52:39 GMT 2025
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PRIMARY | |||
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500717-25-9
Created by
admin on Wed Apr 02 20:52:39 GMT 2025 , Edited by admin on Wed Apr 02 20:52:39 GMT 2025
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NON-SPECIFIC STOICHIOMETRY |
ACTIVE MOIETY
SUBSTANCE RECORD
