CINITAPRIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H30N4O4
Molecular Weight	402.4873
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=C(C=C(C(N)=C1)[N+]([O-])=O)C(=O)NC2CCN(CC3CCC=CC3)CC2

InChI

InChIKey=ZDLBNXXKDMLZMF-UHFFFAOYSA-N

InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9211565 | https://scopeheal.com/cinitapride/

Cinitapride is an agonist of 5-HT4 and 5-HT1 receptors and antagonist of 5-HT2 receptors. Cinitapride is marketed worldwide for the treatment of gastrointestinal disorders related to motility such as indigestion or functional or non-ulcer dyspepsia, gastroesophageal reflux diseases, delay in gastric emptying and vomiting.

Approval Year

PubMed

Title	Date	PubMed
[Efficacy and tolerance of cinitapride on the disturbances of gastrointestinal transit].	1991 Jul-Sep	1820589
[Metoclopramide versus cinitapride in the treatment of functional dyspepsia].	1993 Jul	8218764
Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.	1997 Apr	9211565
Effects of cinitapride on gastric ulceration and secretion in rats.	1998 Mar	9562338
[Prokinetic agents as a cause of granulomatous interstitial nephritis].	2007 Dec	18028853
The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole.	2007 Jul	17437965
[Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying].	2009 Dec	19819042

Name

Type

Language

CINITAPRIDE

Official Name

English

CINITAPRIDE [MI]

Common Name

English

CINITAPRIDE [MART.]

Common Name

English

cinitapride [INN]

Common Name

English

PAXAPRIDE

Brand Name

English

Cinitapride [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

A03FA08