CANDESARTAN CILEXETIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C33H34N6O6
Molecular Weight	610.6597
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)C(=CC=C2)C(=O)OC(C)OC(=O)OC6CCCCC6

InChI

InChIKey=GHOSNRCGJFBJIB-UHFFFAOYSA-N

InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020838s039lbl.pdf
Curator's Comment: description was created based on several sources, including http://www.japsonline.com/admin/php/uploads/290_pdf.pdf

Candesartan is classified as an angiotensin II receptor type 1 antagonist. Candesartan is an orally active lipophilic drug and possesses rapid oral absorption. It causes a reduction in blood pressure and is used in the treatment of hypertension. It is also used in the treatment of congestive heart failure and given as prophylaxis to reduce the severity and duration of migraine. Candesartan cilexetil, a prodrug of Candesartan, is available in the market under the trade names Atacand, Amias. Candesartan cilexetil is rapidly converted to candesartan, its active metabolite, during absorption from the gastrointestinal tract. Candesartan confers blood pressure lowering effects by antagonizing the hypertensive effects of angiotensin II via the RAAS (renin–angiotensin–aldosterone system). RAAS is a homeostatic mechanism for regulating hemodynamics, water, and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering the cardiovascular structure. Angiotensin II binds to two receptors: type-1 angiotensin II receptor (AT1) and type-2 angiotensin II receptor (AT2). Candesartan selectively blocks the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. This inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in an overall decrease in blood pressure. Candesartan is greater than 10,000 times more selective for AT1 than AT2.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Type-1 angiotensin II receptor 41 Target ID: CHEMBL227 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020838s039lbl.pdf	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020838s039lbl.pdf	Primary		Approved 8583	ATACAND Approved Use Candesartan Cilexetil Tablets are an angiotensin II receptor blocker (ARB) indicated for: •Treatment of hypertension in adults and children 1 to < 17 years of age (1.1). •Treatment of heart failure (NYHA class II-IV); candesartan cilexetil tablets reduces cardiovascular death and heart failure hospitalization (1.2). 1.1 Hypertension Candesartan cilexetil tablets are indicated for the treatment of hypertension in adults and children 1 to < 17 years of age. It may be used alone or in combination with other antihypertensive agents. 1.2 Heart Failure Candesartan cilexetil tablets is indicated for the treatment of heart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction ≤ 40%) to reduce cardiovascular death and to reduce heart failure hospitalizations [see CLINICAL STUDIES (14.2) Launch Date 1998
Heart failure 106 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020838s039lbl.pdf	Primary		Approved 8583	ATACAND Approved Use Candesartan Cilexetil Tablets are an angiotensin II receptor blocker (ARB) indicated for: •Treatment of hypertension in adults and children 1 to < 17 years of age (1.1). •Treatment of heart failure (NYHA class II-IV); candesartan cilexetil tablets reduces cardiovascular death and heart failure hospitalization (1.2). 1.1 Hypertension Candesartan cilexetil tablets are indicated for the treatment of hypertension in adults and children 1 to < 17 years of age. It may be used alone or in combination with other antihypertensive agents. 1.2 Heart Failure Candesartan cilexetil tablets is indicated for the treatment of heart failure (NYHA class II-IV) in adults with left ventricular systolic dysfunction (ejection fraction ≤ 40%) to reduce cardiovascular death and to reduce heart failure hospitalizations [see CLINICAL STUDIES (14.2) Launch Date 1998

C_max

Value	Dose	Analyte	Population
55 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
79 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
61 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
92 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
485 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1359 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
509 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1152 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
6.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
12 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
15.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/10192757	8 mg 1 times / day multiple, oral dose: 8 mg route of administration: Oral experiment type: MULTIPLE co-administered:	CANDESARTAN CILEXETIL serum	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
1% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020838s041lbl.pdf	unknown, unknown		CANDESARTAN CILEXETIL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
16 mg 1 times / day steady, oral Recommended Dose: 16 mg, 1 times / day Route: oral Route: steady Dose: 16 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/11141435	unhealthy, 41 years Health Status: unhealthy Age Group: 41 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/11141435	Disc. AE: Hepatitis... AEs leading to discontinuation/dose reduction: Hepatitis (acute, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/11141435
32 mg 1 times / day steady, oral Highest studied dose Dose: 32 mg, 1 times / day Route: oral Route: steady Dose: 32 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/12502672	unhealthy, 59 years Health Status: unhealthy Age Group: 59 years Sources: https://pubmed.ncbi.nlm.nih.gov/12502672	Sources: https://pubmed.ncbi.nlm.nih.gov/12502672
23 mg 1 times / day steady, oral Recommended Dose: 23 mg, 1 times / day Route: oral Route: steady Dose: 23 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy, 67 years Health Status: unhealthy Age Group: 67 years Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	Disc. AE: Hypotension, Hyperkalemia... AEs leading to discontinuation/dose reduction: Hypotension (4.1%) Hyperkalemia (2.4%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
16 mg 1 times / day steady, oral Recommended Dose: 16 mg, 1 times / day Route: oral Route: steady Dose: 16 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	Other AEs: Disorder fetal... Other AEs: Disorder fetal Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
2 mg 1 times / day steady, oral Dose: 2 mg, 1 times / day Route: oral Route: steady Dose: 2 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	Disc. AE: Headache, Dizziness... AEs leading to discontinuation/dose reduction: Headache (0.6%) Dizziness (0.3%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf

AEs

AE	Significance	Dose	Population
Hepatitis	acute, 1 patient Disc. AE	16 mg 1 times / day steady, oral Recommended Dose: 16 mg, 1 times / day Route: oral Route: steady Dose: 16 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/11141435	unhealthy, 41 years Health Status: unhealthy Age Group: 41 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/11141435
Hyperkalemia	2.4% Disc. AE	23 mg 1 times / day steady, oral Recommended Dose: 23 mg, 1 times / day Route: oral Route: steady Dose: 23 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy, 67 years Health Status: unhealthy Age Group: 67 years Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
Hypotension	4.1% Disc. AE	23 mg 1 times / day steady, oral Recommended Dose: 23 mg, 1 times / day Route: oral Route: steady Dose: 23 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy, 67 years Health Status: unhealthy Age Group: 67 years Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
Disorder fetal		16 mg 1 times / day steady, oral Recommended Dose: 16 mg, 1 times / day Route: oral Route: steady Dose: 16 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
Dizziness	0.3% Disc. AE	2 mg 1 times / day steady, oral Dose: 2 mg, 1 times / day Route: oral Route: steady Dose: 2 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf
Headache	0.6% Disc. AE	2 mg 1 times / day steady, oral Dose: 2 mg, 1 times / day Route: oral Route: steady Dose: 2 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020838s036lbl.pdf

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:3347	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3347
ChemicalBook	CB0209324	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB0209324
eMolecules	32278092	https://www.emolecules.com/cgi-bin/more?vid=32278092
eMolecules	901501	https://www.emolecules.com/cgi-bin/more?vid=901501
MolPort	MolPort-003-845-570	https://www.molport.com/shop/molecule-link/MolPort-003-845-570
MolPort	MolPort-005-943-739	https://www.molport.com/shop/molecule-link/MolPort-005-943-739
Selleck Chemicals	Candesartan(Atacand)	http://www.selleckchem.com/products/Candesartan(Atacand).html
ZINC	ZINC000003782818	http://zinc15.docking.org/substances/ZINC000003782818

PubMed

Title	Date	PubMed
Effects of angiotensin II type 1 receptor antagonist (candesartan) in preventing fatal ventricular arrhythmias in dogs during acute myocardial ischemia and reperfusion.	2001-11	11602819
Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritis.	2001-11	11592949
ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts.	2001-10-12	11597988
Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells.	2001-10-09	11591607
Do vascular compartments differ in the development of chronic rejection? AT(1) blocker candesartan versus Ace blocker enalapril in an experimental heart transplant model.	2001-10	11595564
Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure.	2001-10	11593113
Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degeneration.	2001-10	11593105
Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats.	2001-10	11584371
TCV-116 stimulates eNOS and caveolin-1 expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats.	2001-10	11583714
Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure.	2001-10	11579362
Autoregulated glomerular filtration rate during candesartan treatment in hypertensive type 2 diabetic patients.	2001-10	11576357
pK(a) determination of angiotensin II receptor antagonists (ARA II) by spectrofluorimetry.	2001-10	11489393
Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries.	2001-09	11522611
Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress.	2001-09	11517166
Functional role of endogenous endothelin-1 in congestive heart failure treated with angiotensin II receptor antagonist.	2001-08	11564281
Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.	2001-08	11518847
Role of nNOS in regulation of renal function in angiotensin II-induced hypertension.	2001-08	11509490
[Angiotensin II receptor antagonists: different or equivalent?].	2001-07-27	11471284
Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma.	2001-07-17	11457745
Cardioprotection with angiotensin converting enzyme inhibitor and angiotensin II type 1 receptor antagonist is not abolished by nitric oxide synthase inhibitor in ischemia-reperfused rabbit hearts.	2001-07	11510753
The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats.	2001-07	11508274
A forced titration study of antihypertensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II.	2001-07	11464257
Activation of angiotensin II subtype 2 receptor induces catecholamine release in an extracellular Ca(2+)-dependent manner through a decrease of cyclic guanosine 3',5'-monophosphate production in cultured porcine adrenal medullary chromaffin Cells.	2001-07	11416030
Angiotensin receptor blockers for chronic heart failure and acute myocardial infarction.	2001-07	11410575
Angiotensin II activates the GFAT promoter in mesangial cells.	2001-07	11399656
Antihypertensive efficacy of candesartan in comparison to losartan: the CLAIM study.	2001-06-21	11416677
Case of adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with possible adrenal hypersensitivity to angiotensin II.	2001-06	11572327
Possible roles of cardiac chymase after myocardial infarction in hamster hearts.	2001-06	11459123
In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist.	2001-06	11451212
Efficacy of candesartan cilexetil as add-on therapy in hypertensive patients uncontrolled on background therapy: a clinical experience trial. ACTION Study Investigators.	2001-06	11411737
Coronary hemodynamic and ventricular responses to angiotensin type 1 receptor inhibition in SHR: interaction with angiotensin type 2 receptors.	2001-06	11408384
Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.	2001-06	11403355
Effects of TCV-116 on expression of NOS and adrenomedullin in failing heart of Dahl salt-sensitive rats.	2001-06	11395021
Dose-dependent blockade of the angiotensin II type 1 receptor with losartan in normal volunteers.	2001-06	11392465
Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt.	2001-06	11353669
Significance of exaggerated natriuresis after angiotensin AT1 receptor blockade or angiotensin- converting enzyme inhibition in obese Zucker rats.	2001-05-31	11380518
Angiotensin-II-receptor inhibitors in pregnancy.	2001-05-19	11386315
Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis.	2001-05-17	11388887
[Change from ACE inhibitor, Ca-antagonist or beta-blocker to candesartan cilexetil: better efficacy and tolerance. SWITCH study (German study segment)].	2001-05-11	11402910
An angiotensin II type 1 receptor blocker, candesartan, increases myocardial apoptosis in rats with acute ischemia-reperfusion.	2001-05	11409658
Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture.	2001-05	11358950
Angiotensin type 1 receptor antagonism and ACE inhibition produce similar renoprotection in N(omega)-nitro-L>-arginine methyl ester/spontaneously hypertensive rats.	2001-05	11358938
A candesartan cilexetil/hydrochlorothiazide combination tablet provides effective blood pressure control in hypertensive patients inadequately controlled on monotherapy.	2001-05	11349825
Protective effect of agiotensin II type I receptor antagonist, CV-11974, on ischemia and reperfusion injury of the liver.	2001-04-27	11374397
Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats).	2001-04	11388646
Pharmacological differences among angiotensin II receptor antagonists.	2001	11465912
[Angiotensin II type-1 receptor antagonists and diabetes mellitus].	2001	11450165
[Angiotensin I receptor blockers for heart failure].	2001	11450163
[Angiotensin receptor blockers--significance for the therapy of hypertension].	2001	11450162
Angiotensin II AT(1) receptor antagonists and platelet activation.	2001	11369820

Patents

Sample Use Guides

In Vivo Use Guide

Adult Hypertension: 2 DOSAGE AND ADMINISTRATION 2.1 Adult Hypertension The usual recommended starting dose of ATACAND (candesartan cilexetil) is 16 mg once daily when it is used as monotherapy in patients who are not volume depleted. ATACAND can be administered once or twice daily with total daily doses ranging from 8 mg to 32 mg. Pediatric Hypertension 1 to < 17 Years of Age: Children 1 to < 6 years of age: The dose range is 0.05 to 0.4 mg/kg per day. The recommended starting dose is 0.20 mg/kg (oral suspension). Children 6 to < 17 years of age: For those less than 50 kg, the dose range is 2 to 16 mg per day. The recommended starting dose is 4 to 8 mg. For those greater than 50 kg, the dose range is 4 to 32 mg per day. The recommended starting dose is 8 to 16 mg. Adult Heart Failure: The recommended initial dose for treating heart failure is 4 mg once daily. The target dose is 32 mg once daily, which is achieved by doubling the dose at approximately 2-week intervals, as tolerated by the patient.

Route of Administration: Oral

In Vitro Use Guide

Primary cultures of human retinal endothelial cells (EC) were candesartan treatment (1μg/ml).

Name

Type

Language

CANDESARTAN 1-(((CYCLOHEXYLOXY)CARBONYL)OXY)ETHYL ESTER

Preferred Name

English

CANDESARTAN CILEXETIL

Official Name

English

ATACAND

Brand Name

English

CANDESARTAN CILEXETIL [VANDF]

Common Name

English

CANDESARTAN CILEXETIL [USP-RS]

Common Name

English

CANDESARTAN CILEXETIL [MART.]

Common Name

English

TCV-116

Code

English

1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID, 2-ETHOXY-1-((2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-, 1-(((CYCLOHEXYLOXY)CARBONYL)OXY)ETHYL ESTER, (±)-

Common Name

English

CANDESARTAN CILEXETIL [USAN]

Common Name

English

NSC-758697

Code

English

CANDESARTAN CILEXETIL [ORANGE BOOK]

Common Name

English

CANDESARTAN 1-(((CYCLOHEXYLOXY)CARBONYL)OXY)ETHYL ESTER [MI]

Common Name

English

CANDESARTAN CILEXETIL [EP MONOGRAPH]

Common Name

English

CANDESARTAN CILEXETIL [USP MONOGRAPH]

Common Name

English

(±)-1-HYDROXYETHYL 2-ETHOXY-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)-7-BENZIMIDAZOLECARBOXYLATE, CYCLOHEXYL CARBONATE (ESTER)

Common Name

English

Candesartan cilexetil [WHO-DD]

Common Name

English

CANDESARTAN CILEXETIL [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66930