Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H21N3O3.ClH |
Molecular Weight | 327.806 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@]12ON(C)CC[C@@]1(C)C3=C(C=CC(OC(=O)NC)=C3)N2C
InChI
InChIKey=SJOUQRORBYWGNU-SLHAJLBXSA-N
InChI=1S/C15H21N3O3.ClH/c1-15-7-8-17(3)21-13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1H/t13-,15-;/m0./s1
Eseridine (Geneserine) has been known for many years as an anticholinergic agent and used in therapy as a gastrointestinal antispastic. Eseridine salicylate is an inhibitor of cholinesterase activity that has been given by mouth in preparations for dyspepsia and other gastric disorders. It has also been studied for the treatment of Alzheimer’s disease.
Originator
Sources: http://jpet.aspetjournals.org/content/46/4/375
Curator's Comment: Eseridine was first discovered by Eber in 1888 and first obtained in crystal form by Behringer. Merck has stated that eseridine and geneserine, first obtained by Polonovski and Nitzberg in 1915, are identical.
Approval Year
PubMed
Title | Date | PubMed |
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[Determination of geneserine in pharmaceutical solutions]. | 1958 Mar-Apr |
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[Studies of the effect of geneserine, carbamoyl-choline and acetyl-beta-methyl-choline and other related substances on the thyroid gland of the guinea pig]. | 1959 |
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Geneserine and geneseroline revisited: acid-base catalyzed equilibria of hexahydropyrrolo-[2,3-b]-indole N-oxides with hexahydro-1,2-oxazino-[5,6-b]-indoles. | 1989 Mar-Apr |
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Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. | 2002 Aug 15 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.doctissimo.fr/medicament-GENESERINE-3.htm
Adult: 30 to 45 drops, 3 times a day, preferably taken 1/2 hour before main meals.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12166941
Geneserine hydrochloride inhibited human Acetylcholinesterase with IC50 value of 100 nM.
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ACTIVE MOIETY
SUBSTANCE RECORD