PIROCTONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H23NO2
Molecular Weight	237.3379
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C

InChI

InChIKey=OIQJEQLSYJSNDS-UHFFFAOYSA-N

InChI=1S/C14H23NO2/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5/h6,8,11,17H,7,9H2,1-5H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21282741 | https://www.ncbi.nlm.nih.gov/pubmed/21272039

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dandruff 7 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21272039	Primary		Not Provided 504	Unknown Approved Use Unknown
Myeloma 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21282741	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.	2002 Oct	18498517
Effect of residence time on the efficacy of antidandruff shampoos.	2003 Dec	18494909
Enhanced delivery of an anti-dandruff active in a shampoo vehicle.	2004	15645098
[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].	2005 Sep	16329615
In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans.	2006 May	16681805
Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial.	2008 Mar	18269596
The in vitro effect of a collagenolytic enzyme inhibitor on lesion development in root dentin.	2009 Apr	19626976
Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.	2010 May	20546226

Patents

Sample Use Guides

In Vivo Use Guide

shampoo

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

PIROCTONE

Official Name

English

PIROCTONOL

Common Name

English

PIROCTONE [USAN]

Common Name

English

PIROCTONE [MI]

Common Name

English

Piroctone [WHO-DD]

Common Name

English

piroctone [INN]

Common Name

English

1-HYDROXY-4-METHYL-6(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78284