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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H37NO4S
Molecular Weight 471.652
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AGANEPAG ISOPROPYL

SMILES

CCCCC[C@H](O)C1=CC=C(C=C1)N2[C@@H](CCCC3=CC=C(S3)C(=O)OC(C)C)CCC2=O

InChI

InChIKey=GKRBCKDGBDUAIQ-URXFXBBRSA-N
InChI=1S/C27H37NO4S/c1-4-5-6-10-24(29)20-11-13-22(14-12-20)28-21(15-18-26(28)30)8-7-9-23-16-17-25(33-23)27(31)32-19(2)3/h11-14,16-17,19,21,24,29H,4-10,15,18H2,1-3H3/t21-,24-/m0/s1

HIDE SMILES / InChI
Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor. Aganepag can be used in the research of wound healing, scar reduction, scar prevention and wrinkle treatment and prevention. Aganepag is an antiglaucoma agent.

Approval Year

PubMed

PubMed

TitleDatePubMed
Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma.
2019 Apr
Patents

Sample Use Guides

Aganepag (Compound 3) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM
Name Type Language
AGANEPAG ISOPROPYL
USAN   WHO-DD  
USAN  
Official Name English
AGANEPAG ISOPROPYL [USAN]
Common Name English
2-THIOPHENECARBOXYLIC ACID, 5-(3-((2S)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXO-2- PYRROLIDINYL)PROPYL)-, 1-METHYLETHYL ESTER
Common Name English
Aganepag isopropyl [WHO-DD]
Common Name English
AGN-210961
Code English
1-METHYLETHYL 5-(3-((2S)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXOPYRROLIDIN-2- YL)PROPYL)THIOPHENE-2-CARBOXYLATE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29705
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C142904
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
PRIMARY
CAS
910562-20-8
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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PUBCHEM
46928007
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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USAN
YY-25
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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SMS_ID
300000044557
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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FDA UNII
R096XE6760
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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ChEMBL
CHEMBL2105714
Created by admin on Fri Dec 15 19:16:55 GMT 2023 , Edited by admin on Fri Dec 15 19:16:55 GMT 2023
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