AGANEPAG ISOPROPYL

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H37NO4S
Molecular Weight	471.652
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCCCC[C@H](O)C1=CC=C(C=C1)N2[C@@H](CCCC3=CC=C(S3)C(=O)OC(C)C)CCC2=O

InChI

InChIKey=GKRBCKDGBDUAIQ-URXFXBBRSA-N

InChI=1S/C27H37NO4S/c1-4-5-6-10-24(29)20-11-13-22(14-12-20)28-21(15-18-26(28)30)8-7-9-23-16-17-25(33-23)27(31)32-19(2)3/h11-14,16-17,19,21,24,29H,4-10,15,18H2,1-3H3/t21-,24-/m0/s1

HIDE SMILES / InChI

Description

Aganepag isopropyl, an IOP-lowering agent, is an antiglaucoma agent. It is a selective EP2 receptor agonist.

Originator

Approval Year

PubMed

Show entries

Title	Date	PubMed
Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma.	2019 Apr	29669171

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Patents

Sample Use Guides

In Vitro Use Guide

Aganepag (Compound 3) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM

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Name

Type

Language

AGANEPAG ISOPROPYL

Official Name

English

AGN-210961

Preferred Name

English

AGANEPAG ISOPROPYL [USAN]

Common Name

English

2-THIOPHENECARBOXYLIC ACID, 5-(3-((2S)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXO-2- PYRROLIDINYL)PROPYL)-, 1-METHYLETHYL ESTER

Common Name

English

Aganepag isopropyl [WHO-DD]

Common Name

English

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Classification Tree

Code System

Code

Agent Affecting Organs of Special Senses

NCI_THESAURUS

C29705

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Code System

Code

Type

Description

NCI_THESAURUS

C142904

PRIMARY

CAS

910562-20-8

PRIMARY

PUBCHEM

46928007

PRIMARY

USAN

YY-25

PRIMARY

SMS_ID

300000044557

PRIMARY

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ACTIVE MOIETY


					ODT7ZEW9O7

AGANEPAG

SUBSTANCE RECORD


					R096XE6760

AGANEPAG ISOPROPYL