U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C14H18O3
Molecular Weight 234.2909
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of STIRIPENTOL

SMILES

CC(C)(C)C(O)\C=C\C1=CC=C2OCOC2=C1

InChI

InChIKey=IBLNKMRFIPWSOY-FNORWQNLSA-N
InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000664/WC500036518.pdf

Stiripentol is an anticonvulsant drug used in the treatment of epilepsy. It recently proved to increase the GABAergic transmission in vitro in an experimental model of immature rat. Clinical studies were based on the fact that STP also acts as an inhibitor of CYP3A4, CYP1A2, and CYP2C19 in vivo in epileptic patients. Side effects are largely due to the increase in plasma concentrations of other anticonvulsants and can be reduced by lowering the dose of those drugs. Nausea and vomiting are particularly noted when used in combination with sodium valproate. It appears to increase the potency of phenobarbital, primidone, phenytoin, carbamazepine, clobazam and diazepam.

CNS Activity

CNS Active
4002
Curator's Comment: Known to be CNS penetrant in rats. Human data not available.

Originator

BIOCODEX
1
Curator's Comment: The product was first identified by BIOCODEX, in 1978 with early clinical development starting in 1980s.

Approval Year

2018
425
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
846
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
Diacomit

Approved Use

It is indicated for treating severe myoclonic epilepsy in infancy (SMEI, also know as Dravet's syndrome).

Launch Date

2001
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2.1 mg/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
6.5 mg/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
14 mg/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
2000 mg single, oral
dose: 2000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
8.3 mg × h/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
31 mg × h/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
88 mg × h/L
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
2000 mg single, oral
dose: 2000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
7.7 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
10 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/24725808/
2000 mg single, oral
dose: 2000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STIRIPENTOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FED
Doses

Doses

DosePopulationAdverse events​
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Other AEs: Nausea, Vomiting...
Other AEs:
Nausea (15%)
Vomiting (9%)
Salivary hypersecretion (6%)
Fatigue (9%)
Pyrexia (6%)
Bronchitis (6%)
Nasopharyngitis (6%)
Weight decreased (27%)
Weight increased (6%)
Decreased appetite (46%)
Somnolence (67%)
Ataxia (27%)
Hypotonia (18%)
Tremor (15%)
Dysarthria (12%)
Agitation (27%)
Insomnia (12%)
Aggression (9%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Disc. AE: Status epilepticus, Drowsiness...
AEs leading to
discontinuation/dose reduction:
Status epilepticus (< 1%)
Drowsiness (< 1%)
Balance impaired NOS (< 1%)
Sialorrhea (< 1%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
AEs

AEs

AESignificanceDosePopulation
Dysarthria 12%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Insomnia 12%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Nausea 15%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Tremor 15%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Hypotonia 18%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Agitation 27%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Ataxia 27%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Weight decreased 27%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Decreased appetite 46%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Bronchitis 6%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Nasopharyngitis 6%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Pyrexia 6%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Salivary hypersecretion 6%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Weight increased 6%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Somnolence 67%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Aggression 9%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Fatigue 9%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Vomiting 9%
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Balance impaired NOS < 1%
Disc. AE
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Drowsiness < 1%
Disc. AE
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Sialorrhea < 1%
Disc. AE
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Status epilepticus < 1%
Disc. AE
50 mg/kg 1 times / day steady, oral
Recommended
Dose: 50 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg/kg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
unhealthy, mean age 9.2 years
Health Status: unhealthy
Age Group: mean age 9.2 years
Sex: M+F
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1946

inducer
1087
substrate
1193

inhibitor
2438
substrate
1388

inhibitor
2507

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
2153

CYP2B6
926

CYP2C19
2057

CYP2C8
1057

CYP3A
227

P-gp
1741

BCRP
910

OATP1B1
1079

OATP1B3
961

OAT1
725

OAT3
747

OCT2
779
CYP1A2
1197

CYP2C19
1119

CYP3A5
446

UGT
219

P-gp
2052

BCRP
697

OATP1B1
503

OATP1B3
435

OAT1
395

OAT3
391

OCT2
434
CYP1A2
832

CYP2B6
669
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2C9
2497
 no [IC50 130 uM]
CYP2D6
2546
 no
OAT1
730
 not significant
OAT3
749
 not significant
OATP1B1
1095
 not significant
OATP1B3
970
 not significant
OCT2
782
 not significant
CYP3A
317
 yes [IC50 13 uM]
CYP2B6
1160
 yes [IC50 14 uM]
BCRP
985
 yes [IC50 2.34 uM]
CYP1A2
2333
 yes [IC50 6.6 uM]
CYP2C8
1117
 yes [IC50 6.8 uM]
CYP2C19
2141
 yes [IC50 9.2 uM]
P-gp
1932
 yes [IC50 92.1 uM]
CYP1A2
2333
 yes
CYP2B6
1160
 yes
CYP3A4
2633
 yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
BCRP
697
 no
OAT1
395
 no
OAT3
391
 no
OATP1B1
503
 no
OATP1B3
435
 no
OCT2
434
 no
P-gp
2052
 no
CYP1A2
1197
 yes
CYP2C9
1193
 yes
CYP2D6
1388
 yes
CYP3A5
446
 yes
UGT
219
 yes
CYP2C19
1119
 yes
yes (co-administration study)
Comment: Co-administration of clobazam (CYP3A4 substrate) with stiripentol increased concentrations of clobazam by approximately 2-fold and norclobazam (clobazam active metabolite, CYP2C19 substrate) by 5-fold
Page: 14.0
CYP3A4
1946
 yes
yes (co-administration study)
Comment: Co-administration of clobazam (CYP3A4 substrate) with stiripentol increased concentrations of clobazam by approximately 2-fold and norclobazam (clobazam active metabolite, CYP2C19 substrate) by 5-fold
Page: 14.0
Sourcing

Sourcing

Vendor/AggregatorIDURL
1PlusChem LLC
1P00D9HB
1PlusChem LLC
1P01DMPG
A2B Chem
AG18015
AA Blocks
AA00D8XV
AK Scientific
8269AH
Alfa Chemistry
ACM49763964
Angene
AGN-PC-0510R6
ApexBio Technology
A8704
AstaTech
W10731
BLD Pharm
BD151952
BOC Sciences
1185239-64-8
BOC Sciences
49763-96-4
Cayman Chemical
17781
Chem Scene
CS-7801
Combi-Blocks
QN-0342
Compound Cloud
5311454
eMolecules
300095130
eMolecules
36550241
eMolecules
48856676
eMolecules
50580450
Fluorochem
505617
Hangzhou Yuhao Chemical Technology
RT15516
Lab Network
LN01301989
Lab Network
LN01745578
Lab Seeker
SC-53649
mcule
MCULE-1878244070
mcule
MCULE-5305607439
MedChem Express
HY-103392
Molnova
M18654
MolPort
MolPort-005-942-442
MuseChem
R064217
Selleck Chemicals
S5266
ShangHai Biochempartner
BCP10434
Sigma Aldrich
S6826
Sigma Aldrich
S6826|SIGMA
StruChem
SC-53649
TargetMol
T4498
Tetrahedron
TS25569
Toronto Research Chemicals
S686825
WuXi AppTec
WX692001
ZINC
ZINC000000000724
http://zinc15.docking.org/substances/ZINC000000000724
ZINC
ZINC000002005958
http://zinc15.docking.org/substances/ZINC000002005958
ZINC
ZINC000011726811
http://zinc15.docking.org/substances/ZINC000011726811
ZINC
ZINC000022066531
http://zinc15.docking.org/substances/ZINC000022066531
PubMed

PubMed

TitleDatePubMed
Stiripentol.
2005-07
Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures.
1999-09
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
1996-10
Patents

Patents

EP0501889 A2
1
US5095033 A
1

Sample Use Guides

In Vivo Use Guide
Initial dose is 50 mg/kg per day. This may be increased up to 100 mg/kg per day, with a maximum of 4 g/day.
Route of Administration: Oral
In Vitro Use Guide
stiripentol was found to reduce synaptosomal GABA uptake (IC50 5x10-5) and to slightly increase (+22%) brain concentrations of GABA after “in vivo” administration (300 mg/kg i.p.).
Name Type Language
DIACOMIT
Preferred Name English
STIRIPENTOL
EMA EPAR   INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
BCX-2600
Code English
STIRIPENTOL [MI]
Common Name English
STIRIPENTOL [MART.]
Common Name English
Stiripentol [WHO-DD]
Common Name English
STIRIPENTOL [USAN]
Common Name English
STIRIPENTOL [ORANGE BOOK]
Common Name English
1-(1,3-BENZODIOXOL-5-YL)-4,4-DIMETHYL-1-PENTEN-3-OL
Systematic Name English
BCX 2600
Code English
STIRIPENTOL [EMA EPAR]
Common Name English
stiripentol [INN]
Common Name English
STIRIPENTOL [JAN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 800820
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
EU-Orphan Drug EU/3/01/071
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
WHO-VATC QN03AX17
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
NCI_THESAURUS C264
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
EMA ASSESSMENT REPORTS DIACOMIT (AUTHORIZED: MYOCLONIC EPILEPSY, JUVENILE)
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
FDA ORPHAN DRUG 266108
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
WHO-ATC N03AX17
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
Code System Code Type Description
DRUG CENTRAL
2480
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
MERCK INDEX
m10218
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID80860609
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
CAS
137767-55-6
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
FDA UNII
R02XOT8V8I
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
RXCUI
2054968
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
INN
3760
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
CAS
131206-47-8
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
SUPERSEDED
MESH
C021092
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
CAS
49763-96-4
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
NON-SPECIFIC STEREOCHEMISTRY
LACTMED
Stiripentol
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
SMS_ID
100000089171
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
WIKIPEDIA
STIRIPENTOL
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
IUPHAR
5469
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
ChEMBL
CHEMBL1983350
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
DAILYMED
R02XOT8V8I
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
EVMPD
SUB10654MIG
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
DRUG BANK
DB09118
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
ECHA (EC/EINECS)
256-480-9
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
NCI_THESAURUS
C152433
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
PUBCHEM
5311454
Created by admin on Mon Mar 31 19:40:55 GMT 2025 , Edited by admin on Mon Mar 31 19:40:55 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of STIRIPENTOL
METABOLITE INACTIVE (PARENT)
Structure of STIRIPENTOL GLUCURONIDE
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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