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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H19N3O2
Molecular Weight 273.3303
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAVACAMTEN

SMILES

CC(C)N1C(=O)NC(N[C@@H](C)C2=CC=CC=C2)=CC1=O

InChI

InChIKey=RLCLASQCAPXVLM-NSHDSACASA-N
InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1

HIDE SMILES / InChI
MYK-461 (also known as Mavacamten) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy, one of the most prevalent heritable cardiovascular disorders. Studies on isolated cells and muscle fibers, as well as intact animals, have shown that MYK-461 inhibits sarcomere force production, thereby reducing cardiac contractility. In Phase II clinical trials MYK-461 reduces left ventricular outflow tract obstruction and improve exercise capacity and symptoms in patients with obstructive hypertrophic cardiomyopathy. Phase III clinical trials are currently ongoing.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.3 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.
2019 Jun 4
Patents

Patents

Sample Use Guides

10 to 20 mg/day
Route of Administration: Oral
Name Type Language
MAVACAMTEN
INN  
INN   USAN  
Official Name English
Mavacamten [WHO-DD]
Common Name English
CAMZYOS
Brand Name English
SAR-439152
Code English
2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-
Systematic Name English
3-(1-Methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione
Systematic Name English
MAVACAMTEN [USAN]
Common Name English
MYK-461
Code English
mavacamten [INN]
Common Name English
6-{[(1S)-1-phenylethyl]amino}-3-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 515015
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
Code System Code Type Description
SMS_ID
300000002681
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
PUBCHEM
117761397
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
DRUG BANK
DB14921
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
DAILYMED
QX45B99R3J
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
CAS
1642288-47-8
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
FDA UNII
QX45B99R3J
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
RXCUI
2600867
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
NCI_THESAURUS
C174901
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
USAN
JK-199
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY
INN
10492
Created by admin on Sat Dec 16 09:03:44 UTC 2023 , Edited by admin on Sat Dec 16 09:03:44 UTC 2023
PRIMARY