| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H6O4 |
| Molecular Weight | 166.1308 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C2OCOC2=C1
InChI
InChIKey=VDVJGIYXDVPQLP-UHFFFAOYSA-N
InChI=1S/C8H6O4/c9-8(10)5-1-2-6-7(3-5)12-4-11-6/h1-3H,4H2,(H,9,10)
Piperonylic acid is a natural molecule contains in Piper nigrum and bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Purified piperonylic acid is water-soluble, secure and nontoxic. Recent researchers have verified that piperonylic acid not only inhibited the growth of cancer cells and regulated the immunity, but also improved the lipid metabolism, enhanced endothelial function, and resisted atherosclerotic proliferation. However, related experimental studies are still limited.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 43.0 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
Sample Use Guides
The rats were intragastrically administered with 3 ml of piperonylic acid (10 g/L) daily
Route of Administration:
Oral
VSMCs were inoculated on 96-well culture plates (1×10^6/L), and the culture medium was refreshed after 48 h and then discarded when 90 % of the cells fused, with serum-free DMEM culture medium used instead. The cells were then starved for 48 h to be synchronized in the G0 phase. 50 μl of pH7.4 PBS was added into each well of the control group, 5 % FBS was added into the FBS group, and piperonylic acid solutions (fi nal concentrations: 20, 40, 60, 80 mg/L) were added into each well of each experimental group respectively. 48 h later, 3H-TdR (3.0×105 Bq/L) was added, 48 h after which the cells were collected. Then the cell membrane was broken, and 3 ml of scintillating solution were added. The radiation intensity was measured by liquid scintillation counting.
SUBSTANCE RECORD
