U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C19H18F6N2O.H3O4P
Molecular Weight 502.3446
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ENPIROLINE PHOSPHATE

SMILES

OP(O)(O)=O.[H][C@@]1(CCCCN1)[C@H](O)C2=CC(=NC(=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F

InChI

InChIKey=YCAFBJQXADKUSD-SATBOSKTSA-N
InChI=1S/C19H18F6N2O.H3O4P/c20-18(21,22)13-6-4-11(5-7-13)15-9-12(10-16(27-15)19(23,24)25)17(28)14-3-1-2-8-26-14;1-5(2,3)4/h4-7,9-10,14,17,26,28H,1-3,8H2;(H3,1,2,3,4)/t14-,17-;/m1./s1

HIDE SMILES / InChI
Enpiroline (WR 180,409) is an antimalarial compound. It demonstrates activity against Plasmodium falciparum both in vitro and in non-immune infected subjects. Additionally, it exerts antischistosomal activity.

Approval Year

PubMed

PubMed

TitleDatePubMed
Name Type Language
ENPIROLINE PHOSPHATE
MART.   USAN  
USAN  
Official Name English
ENPIROLINE PHOSPHATE [USAN]
Common Name English
WR 180,409
Code English
ENPIROLINE PHOSPHATE [MART.]
Common Name English
WR-180409
Code English
(±)-(R*,R*)-.ALPHA.-(2-(TRIFLUOROMETHYL)-6-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-4-PYRIDYL)-2-PIPERIDINEMETHANOL PHOSPHATE (1:1) (SALT)
Common Name English
4-PYRIDINEMETHANOL, .ALPHA.-(2-PIPERIDINYL)-2-(TRIFLUOROMETHYL)-6-(4-(TRIFLUOROMETHYL)PHENYL)-, (R*,R*)-(±)-, PHOSPHATE (1:1) (SALT)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C271
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1327821
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
NCI_THESAURUS
C75268
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID60216589
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
PUBCHEM
47910
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
USAN
W-43
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
MESH
C023767
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
FDA UNII
QX39IR9V1D
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY
CAS
66364-74-7
Created by admin on Fri Dec 15 17:18:33 GMT 2023 , Edited by admin on Fri Dec 15 17:18:33 GMT 2023
PRIMARY