Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H14F3N3O4S |
| Molecular Weight | 425.382 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(=O)NC(=O)N(C1=O)C2=CC=C(OC3=CC=C(SC(F)(F)F)C=C3)C(C)=C2
InChI
InChIKey=OCINXEZVIIVXFU-UHFFFAOYSA-N
InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Enzymes of the respiratory cain |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Toltrazuril Approved UsePrevention and treatment of coccidiosis. Launch Date1998 |
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| Curative | Procox Approved UseProcox is used to treat dogs which are infected, or which the veterinary surgeon suspects of being infected, by two types of parasite at the same time, roundworms and coccidia. Launch Date2011 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Haste makes waste: accelerated molt adversely affects the expression of melanin-based and depigmented plumage ornaments in house sparrows. | 2010-12-03 |
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| Isosporoid coccidiosis in translocated cirl buntings (Emberiza cirlus). | 2010-10-23 |
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| Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits. | 2010-10 |
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| Effect of toltrazuril treatment in nursing piglets naturally infected with Isospora suis. | 2010-08-27 |
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| Comparison of toltrazuril and sulphadimethoxine in the treatment of intestinal coccidiosis in pet rabbits. | 2010-08-21 |
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| Drug resistance evaluation of some commonly used anti-coccidial drugs in broiler chickens. | 2010-08 |
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| Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food. | 2010-08 |
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| Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. | 2010-08 |
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| Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration. | 2010-04-19 |
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| Effect of treatment with Neem (Azadirachta indica) compared with Baycox drug on the caecum of chicken experimentally infected with Eimeria tenella. | 2010-04 |
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| Toltrazuril and sulphonamide treatment against naturally Isospora suis infected suckling piglets: is there an actual profit? | 2009-08-26 |
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| Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. | 2009-08 |
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| Study of the comparative efficacy of toltrazuril and diclazuril against ovine coccidiosis in housed lambs. | 2009-08 |
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| Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. | 2009-06 |
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| [Comparison of pretreatment methods for the simultaneous determination of diclazuril and toltrazuril residues in chicken tissues]. | 2009-05 |
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| Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs. | 2009-04 |
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| Relevance and treatment of coccidiosis in domestic pigeons (Columba livia forma domestica) with particular emphasis on toltrazuril. | 2009-03 |
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| An outbreak of cryptosporidiosis in a collection of Stone curlews (Burhinus oedicnemus) in Dubai. | 2008-10 |
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| NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. | 2008-08 |
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| The value of plant extracts with antioxidant activity in attenuating coccidiosis in broiler chickens. | 2008-05-31 |
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| Eimeria stiedae: experimental infection in rabbits and the effect of treatment with toltrazuril and ivermectin. | 2008-05 |
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| Comparative therapeutic effect of toltrazuril, sulphadimidine and amprolium on Eimeria bovis and Eimeria zuernii given at different times following infection in buffalo calves (Bubalus bubalis). | 2008-04-17 |
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| Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae). | 2007-03 |
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| Efficacy of various anticoccidials against experimental porcine neonatal isosporosis. | 2007-01 |
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| Controlling coccidiosis in piglets: the importance of the subclinical infection. | 2007-01 |
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| Effects of toltrazuril on the growth of piglets in herds without clinical isosporosis. | 2007-01 |
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| The efficacy and economic benefits of Supercox, a live anticoccidial vaccine in a commercial trial in broiler chickens in China. | 2006-11-30 |
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| Humoral immune reaction of newborn calves congenitally infected with Neospora caninum and experimentally treated with toltrazuril. | 2006-10 |
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| Treatment of mice with the anticoccidial drug Toltrazuril does not interfere with the development of a specific cellular intestinal immune response to Eimeria falciformis. | 2005-12 |
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| Pathology and treatment of Eimeria zuernii coccidiosis in calves: investigations in an infection model. | 2005-12 |
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| Control of clinical coccidiosis of calves due to Eimeria bovis and Eimeria zuernii with toltrazuril under field conditions. | 2005-10 |
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| Efficacy of toltrazuril as a metaphylactic and therapeutic treatment of coccidiosis in first-year grazing calves. | 2005-10 |
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| Anticoccidial efficacy of drinking water soluble diclazuril on experimental and field coccidiosis in broiler chickens. | 2005-08 |
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| Occurrence of Isospora suis in Germany, Switzerland and Austria. | 2005-03 |
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| Field trial of a Caryospora species vaccine for controlling clinical coccidiosis in falcons. | 2005-01-29 |
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| Toltrazuril treatment to control diaplacental Neospora caninum transmission in experimentally infected pregnant mice. | 2005-01 |
|
| Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo. | 2004-12-13 |
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| Clinical Hepatozoon canis infection in a dog in Turkey. | 2004-12 |
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| The role of B- and T-cell immunity in toltrazuril-treated C57BL/6 WT, microMT and nude mice experimentally infected with Neospora caninum. | 2004-06 |
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| Coccidiosis control by administering toltrazuril in the drinking water for a 2-day period. | 2004-05-07 |
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| Effects of toltrazuril and ponazuril on the fine structure and multiplication of tachyzoites of the NC-1 strain of Neospora caninum (a synonym of Hammondia heydorni) in cell cultures. | 2004-04 |
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| Effects of toltrazuril and ponazuril on Hammondia heydorni (syn. Neospora caninum) infections in mice. | 2004-04 |
|
| [Coccidiosis causes diarrhea in calves in the pasture. Pasture coccidiosis caused by Eimeria alabamensis]. | 2004-03-01 |
|
| Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed. | 2003-07-31 |
|
| Efficacy of toltrazuril against artificial infections with Eimeria bovis in calves. | 2003-07 |
|
| Studies on the efficacy of toltrazuril, diclazuril and sulphadimidine against artificial infections with Isospora suis in piglets. | 2003-07 |
|
| The production and characterisation of an antibody to detect the coccidiostat toltrazuril and its metabolite ponazuril. | 2003-05 |
|
| [The influence of Baycox and Anticoc on the dynamics of Eimeria sp. course in calves]. | 2001 |
|
| Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria. | 1998-10-15 |
|
| Susceptibility of Encephalitozoon cuniculi to several drugs in vitro. | 1995-06 |
Patents
Sample Use Guides
Administration via drinking water at 25 mg/l over 48 h, or at 75 mg/l given for 8h per day for 2 consecutive days (turkeys and chickens). Treatment corresponds to a dose of approximately 7 mg/kg bw/day.
In dogs: the recommended minimum dose is 0.5 ml/kg bodyweight (bw), equivalent to 0.45 mg emodepside/kg bw and 9 mg toltrazuril/kg bw.
Route of Administration:
Oral
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NCI_THESAURUS |
C277
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WHO-VATC |
QP51AJ01
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WHO-VATC |
QP52AX60
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EMA VETERINARY ASSESSMENT REPORTS |
PROCOX [AUTHORIZED]
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CHEMBL2104931
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Z-55
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759176
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TOLTRAZURIL
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69004-03-1
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QVZ3IAR3JS
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C72601
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C036670
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DTXSID90219063
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m10955
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ACTIVE MOIETY
METABOLITE (PARENT)
