U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula ClH
Molecular Weight 36.461
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Hydrochloric Acid

SMILES

Cl

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-N
InChI=1S/ClH/h1H

HIDE SMILES / InChI

Description

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

1921
1468
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

1971
PubMed

PubMed

TitleDatePubMed
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.
2015-01-05
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.
2013-12-15
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.
2013-02
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.
2011-05
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells.
2011-02
The effect of tidal volume on systemic inflammation in Acid-induced lung injury.
2011
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.
2010-11-29
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
2010-11
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
2010-11
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
2010-10
Altered sensorimotor responses to esophageal acidification in older adults with GERD.
2010-10
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
2010-09
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.
2010-08
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010-08
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
2010-08
NHE4 is critical for the renal handling of ammonia in rodents.
2010-06
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
2010
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.
2010
Animal study for airway inflammation triggered by gastroesophageal reflux.
2009-11-20
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.
2009-11
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.
2009-10
Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.
2009-09
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.
2009-08
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
2009-07-15
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].
2009-06
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.
2009-06
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
2009-05
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.
2009-04-01
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.
2009-04
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.
2009-03
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.
2009-02
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
2009-01
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.
2008-09
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.
2008-08
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].
2008-06
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.
2008-06
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.
2008-06
TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.
2008-05-16
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.
2008-05
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.
2008-04-23
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.
2008-03
Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.
2008-02
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.
2007-10
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.
2007-09-01
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.
2007-07-14
Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.
2007-06-01
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.
1996-02
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
1991-09
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
1985-08
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.
1982-10
Patents

Patents

03931143
18
03931151
3
03931217
11
03931239
40
03932426
35
03932479
113
03932524
68
03932644
2
03933802
2
03933906
2
03934024
2
03936418
3
03937704
32
03940411
10
03940421
2
03940486
2
03943154
10
03946001
3
03947417
2
03947445
3
03947582
13
03948955
2
03950380
3
03950390
2
03950393
3
03950406
119
03950423
2
03951976
2
03951980
4
03953402
2
Name Type Language
Hydrochloric Acid
FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
MURIATICUM ACIDUM
HPUS  
Preferred Name English
BAUME HCL
Common Name English
E-507
Code English
HYDROCHLORIC ACID [MART.]
Common Name English
MURIATICUM ACIDUM [HPUS]
Common Name English
ACIDUM HYDROCHLORICUM [WHO-IP LATIN]
Common Name English
HYDROCHLORIC ACID [JAN]
Common Name English
ICON ETCH
Common Name English
HYDROCHLORIC ACID [WHO-IP]
Common Name English
HYDROCHLORIC ACID [VANDF]
Common Name English
INS-507
Code English
INS NO.507
Code English
HYDROCHLORIC ACID [FCC]
Common Name English
ANHYDROUS HYDROCHLORIC ACID
Common Name English
HYDROCHLORIC ACID [IARC]
Common Name English
HYDROGEN CHLORIDE
MI  
Systematic Name English
MURIATIC ACID
Common Name English
HYDROCHLORIC ACID [MI]
Common Name English
HYDROGEN CHLORIDE [MI]
Common Name English
HYDROCHLORIC ACID [II]
Common Name English
HYDROCHLORIC ACID [HSDB]
Common Name English
NSC-77365
Code English
Hydrochloric acid [WHO-DD]
Common Name English
ENPLATE PO 236
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 45901
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
WHO-VATC QB05XA13
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
WHO-VATC QA09AB03
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
DSLD 1445 (Number of products:1)
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
JECFA EVALUATION INS-507
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
WHO-ATC A09AB03
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
WHO-ATC B05XA13
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
CODEX ALIMENTARIUS (GSFA) INS-507
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
FDA ORPHAN DRUG 98896
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
Code System Code Type Description
EVMPD
SUB50009
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
CONCEPT Industrial Aid
WHO INTERNATIONAL PHARMACOPEIA
HYDROCHLORIC ACID
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY Description: A clear, colourless, fuming liquid; odour, pungent. Miscibility: Miscible with water. Category: Acidifying agent. Storage: Hydrochloric acid should be kept in a tightly closed container. Additional information: The fumes and odour disappear when the acid is diluted with 2 volumes of water. Mass density: .RHO.20 = about 1.18 g/mL. Requirement: Hydrochloric acid contains not less than 35.0% m/mand not more than the equivalent of 38.0% m/mof HCl.
DRUG CENTRAL
4568
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
RXCUI
5486
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
HYDROCHLORIC ACID
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
NCI_THESAURUS
C76716
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
EVMPD
SUB129759
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
ALTERNATIVE
PUBCHEM
313
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
CAS
7647-01-0
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
CHEBI
17883
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
MERCK INDEX
m6101
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID2020711
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
DAILYMED
QTT17582CB
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
ChEMBL
CHEMBL1231821
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
ECHA (EC/EINECS)
231-595-7
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
MERCK INDEX
m6088
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY Merck Index
MESH
D006851
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
EVMPD
SUB12513MIG
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
FDA UNII
QTT17582CB
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
DRUG BANK
DB13366
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
NSC
77365
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
SMS_ID
100000078724
Created by admin on Mon Mar 31 18:06:52 GMT 2025 , Edited by admin on Mon Mar 31 18:06:52 GMT 2025
PRIMARY
NIH
NCATS
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ACCESSIBILITY
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