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Details

Stereochemistry ACHIRAL
Molecular Formula C13H14N3O4S.Na
Molecular Weight 331.323
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYMIDINE SODIUM

SMILES

[Na+].COCCOC1=CN=C([N-]S(=O)(=O)C2=CC=CC=C2)N=C1

InChI

InChIKey=NUQDEHHKOXSIEA-UHFFFAOYSA-N
InChI=1S/C13H14N3O4S.Na/c1-19-7-8-20-11-9-14-13(15-10-11)16-21(17,18)12-5-3-2-4-6-12;/h2-6,9-10H,7-8H2,1H3;/q-1;+1

HIDE SMILES / InChI
Glymidine (Glycodiazine ) is a hypoglycaemic agent which has been introduced as a possible alternative to the sulphonylurea as and biguanides for the oral treatment of diabetes mellitus. It is one of a group of lipid soluble sulphapyrimidine derivatives synthesized by Gutsche et al. and bears some structural resemlance to tolbutamide. Its mode of action is similar to that of the sulphonylureas in that it appears to stimulate insulin release from the pancreas. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. It is used for the concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P48048
Gene ID: 3758.0
Gene Symbol: KCNJ1
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
[Diabetes mellitus of elderly patients: therapeutic recommendations].
2008 Nov
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Most authors have limited the dose to 1.5g daily, but in the absence of side-effects it would seem reasonable to increase this dose when it has proved inadequate to produce good control.
The potency of glymidine is possibly slightly greater than tolbutamide, the average dose being 0.5g given twice daily, with a range of from 0.5g to 1.5g daily.
Route of Administration: Oral
In Vitro Use Guide
Glymidine exerted photohemolysis in the concentration 10(-4) mol/l
Name Type Language
GLYMIDINE SODIUM
INN   JAN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
glymidine sodium [INN]
Common Name English
GONDAFON
Brand Name English
LYCANOL
Brand Name English
[N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamido] sodium salt
Common Name English
GLYMIDINE SODIUM SALT
MI  
Common Name English
Glymidine sodium [WHO-DD]
Common Name English
SH 717
Code English
GLYMIDINE SODIUM [USAN]
Common Name English
GLYMIDINE SODIUM SALT [MI]
Common Name English
GLYMIDINE SODIUM [JAN]
Common Name English
SH-717
Code English
BENZENESULFONAMIDE, N-(5-(2-METHOXYETHOXY)-2-PYRIMIDINYL)-, SODIUM SALT
Common Name English
REDUL
Brand Name English
GLYCONORMAL
Brand Name English
GLYMIDINE SODIUM [MART.]
Common Name English
Code System Code Type Description
PUBCHEM
23672378
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
PRIMARY
EVMPD
SUB07954MIG
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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SMS_ID
100000084234
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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MERCK INDEX
m5813
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
GLYMIDINE SODIUM
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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INN
1804
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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ChEMBL
CHEMBL1697838
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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NCI_THESAURUS
C174897
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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CHEBI
31660
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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EPA CompTox
DTXSID2057601
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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FDA UNII
QPY3C057X1
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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CAS
3459-20-9
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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ECHA (EC/EINECS)
222-399-2
Created by admin on Fri Dec 15 15:03:41 GMT 2023 , Edited by admin on Fri Dec 15 15:03:41 GMT 2023
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