Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H17NO2 |
| Molecular Weight | 207.2689 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C1OC)[C@H](C)NCC2
InChI
InChIKey=HMYJLVDKPJHJCF-QMMMGPOBSA-N
InChI=1S/C12H17NO2/c1-8-10-7-12(15-3)11(14-2)6-9(10)4-5-13-8/h6-8,13H,4-5H2,1-3H3/t8-/m0/s1
Salsolidine is a simple 1-substituted tetrahydroisoquinoline isolated from many natural sources as the racemate and in its enantiomeric modifications. Stereoselective competitive inhibition of MAO A was found with the R enantiomer of salsolidine (Ki = 6 uM). Salsolidine also inhibits acetylcholinesterase (AChE), and buytlcholinesterase (BChE). Salsolidine may inhibit catechol-O-methyltransferase (COMT). Derivatives of salsolidine are neurotoxic and cytotoxic. R enantiomer of salsolidine is more potent than the S form.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin-streptavidin technology. | 2013 Apr 10 |
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| Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine. | 2013 Jun 10 |
|
| Structural, kinetic, and docking studies of artificial imine reductases based on biotin-streptavidin technology: an induced lock-and-key hypothesis. | 2014 Nov 5 |
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164752
Created by
admin on Fri Dec 15 20:16:51 GMT 2023 , Edited by admin on Fri Dec 15 20:16:51 GMT 2023
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QMS4D62O1I
Created by
admin on Fri Dec 15 20:16:51 GMT 2023 , Edited by admin on Fri Dec 15 20:16:51 GMT 2023
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493-48-1
Created by
admin on Fri Dec 15 20:16:51 GMT 2023 , Edited by admin on Fri Dec 15 20:16:51 GMT 2023
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SUBSTANCE RECORD
