PHENARSONE SULFOXYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10AsNO6S
Molecular Weight	311.144
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C=C1NCS(O)=O)[As](O)(O)=O

InChI

InChIKey=MSEAHRGTAGLWGR-UHFFFAOYSA-N

InChI=1S/C7H10AsNO6S/c10-7-2-1-5(8(11,12)13)3-6(7)9-4-16(14)15/h1-3,9-10H,4H2,(H,14,15)(H2,11,12,13)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20323806 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 958, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/18868767

Phenarsone sulfoxylate (Aldarsone), a pentavalent arsenical, is a condensation product of 3-amino-4 hydroxylphenylarsonic acid with sodium formaldehyde sulfoxylate. It is an antiamoebic agent. Aldarsone has a spirochetal power superior to that of tryparsamide. Aldarsone may be used in conjunction with artificial fever therapy and penicillin therapy to improve the results in symptomatic syphilis of the central nervous system (neurosyphilis).

Approval Year

PubMed

Title	Date	PubMed
Aldarsone therapy in the treatment of general paresis.	1948-08	18888497
Aldarsone and bismuth combined in the treatment of neurosyphilis; report of 100 cases.	1948-07	18868767
Aldarsone and neurosyphilis.	1947-09	20260227
The use of aldarsone in the treatment of neurosyphilis.	1946-06	20983623
ALDARSONE IN NEURO-SYPHILIS.	1946-06	20323806

Name

Type

Language

PHENARSONE SULFOXYLATE

Official Name

English

METHANESULFINIC ACID, 1-((5-ARSONOYL-2-HYDROXYPHENYL)AMINO)-

Preferred Name

English

1-((5-ARSONO-2-HYDROXYPHENYL)AMINO)METHANESULFINIC ACID

Systematic Name

English

phenarsone sulfoxylate [INN]

Common Name

English

Code System Code Type Description

FDA UNII

QEG0T4K3VZ