U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C17H23N3O4.ClH
Molecular Weight 369.843
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Primidolol hydrochloride

SMILES

Cl.CC1=CN(CCNCC(O)COC2=C(C)C=CC=C2)C(=O)NC1=O

InChI

InChIKey=OOHOLIQGGQPTLN-UHFFFAOYSA-N
InChI=1S/C17H23N3O4.ClH/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23;/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23);1H

HIDE SMILES / InChI
Primidolol (also known as UK-11,443) is an imidazolidinone derivative patented by American pharmaceutical corporation Pfizer Corp as a specific β-adrenergic blocker. In clinical trials, Primidolol shows some antihypertensive activity but the overall change in the cardiovascular parameters failed to demonstrate a significant difference compared to placebo.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension.
1980
Immediate cardiovascular responses to oral prazosin--effects of concurrent beta-blockers.
1981 Mar
Patents

Patents

Sample Use Guides

50 mg or 100 mg daily, for a 4 days.
Route of Administration: Oral
Name Type Language
Primidolol hydrochloride
Common Name English
2,4(1H,3H)-Pyrimidinedione, 1-[2-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]ethyl]-5-methyl-, monohydrochloride
Systematic Name English
2,4(1H,3H)-Pyrimidinedione, 1-[2-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]ethyl]-5-methyl-, hydrochloride (1:1)
Systematic Name English
Code System Code Type Description
CAS
40778-40-3
Created by admin on Sat Dec 16 08:36:52 GMT 2023 , Edited by admin on Sat Dec 16 08:36:52 GMT 2023
PRIMARY
FDA UNII
QAT67NBE8Q
Created by admin on Sat Dec 16 08:36:52 GMT 2023 , Edited by admin on Sat Dec 16 08:36:52 GMT 2023
PRIMARY
PUBCHEM
176173
Created by admin on Sat Dec 16 08:36:52 GMT 2023 , Edited by admin on Sat Dec 16 08:36:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID4021187
Created by admin on Sat Dec 16 08:36:52 GMT 2023 , Edited by admin on Sat Dec 16 08:36:52 GMT 2023
PRIMARY