MECONIC ACID MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H4O7.H2O
Molecular Weight	218.1177
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.OC(=O)C1=CC(=O)C(O)=C(O1)C(O)=O

InChI

InChIKey=PUILRPWSVSIQOH-UHFFFAOYSA-N

InChI=1S/C7H4O7.H2O/c8-2-1-3(6(10)11)14-5(4(2)9)7(12)13;/h1,9H,(H,10,11)(H,12,13);1H2

HIDE SMILES / InChI

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0033695 | https://www.henriettes-herb.com/eclectic/bpc1911/acidum-meco.html

Poppy acid occurs in opium (Papaver somniferum) and other Papaver species. Meconic acid has been described as a mild narcotic, but it has little or no physiological action, and is not now used medicinally. Its chemical reactions are of importance in toxicology as a valuable indication of the presence of opium.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Opioid receptor 5 Target ID: CHEMBL2094129 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10768488	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 275 Sources: http://www.google.com.sv/patents/WO2003079976A3	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.	2010-12-21	21203539
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.	2004-10-21	15481971
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.	2004-06-21	15149686
Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric analysis of opiates and metabolites in rat urine after inhalation of opium.	2003-06-05	12726852

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: Meconic acid, taken in a dose of from eight to ten grains, produces no sensible effect upon young and week dogs.

Route of Administration: Oral

In Vitro Use Guide

Effects of comenic and meconic acids on cultured dorsal root ganglion cells were investigated by the whole-cell patch clamp technique. The acids decreased effective charge transfer in the activation gating system of TTX-resistant (slow) sodium channels in a dose-dependent manner. The effects were described by Hill's equation. The dissociation constant and Hill coefficient values were K(D) = 100 nM and X = 0.5 (for comenic acid) and K(D) = 10 nM and X = 0.34 (for meconic acid).

Name

Type

Language

MECONIC ACID MONOHYDRATE

Common Name

English

4H-PYRAN-2,6-DICARBOXYLIC ACID, 3-HYDROXY-4-OXO-, HYDRATE (1:1)

Preferred Name

English

MECONIC ACID MONOHYDRATE [MI]

Common Name

English

4H-PYRAN-2,6-DICARBOXYLIC ACID, 3-HYDROXY-4-OXO-, MONOHYDRATE

Common Name

English

Code System Code Type Description

FDA UNII

Q6X6XN3R4H