ROPIZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H26N4
Molecular Weight	370.49
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC(\C=N\N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)=N1

InChI

InChIKey=UZDGLRYWBSKLQY-NCELDCMTSA-N

InChI=1S/C24H26N4/c1-20-9-8-14-23(26-20)19-25-28-17-15-27(16-18-28)24(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-14,19,24H,15-18H2,1H3/b25-19+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/639771 | https://www.ncbi.nlm.nih.gov/pubmed/762654 | https://www.ncbi.nlm.nih.gov/pubmed/2345483

Ropizone (SC-13504) is an anticonvulsant. This compound both enhances and inhibits [3H]dextromethorphan (DM) high-affinity binding to different areas of the guinea pig brain, suggesting distinct binding site types in the brain. Ropizone was shown to have limited anti-convulsant activity against chemically induced seizures. The drug may have anti-grand mal activity but lacked any anti-petit mal effect in Beagle dogs. No information on the current use of this compound is available.

Approval Year

PubMed

Title	Date	PubMed
Measurement of anticonvulsant activity in the Papio papio model of epilepsy.	1976 Sep	821787

Name

Type

Language

ROPIZINE

Official Name

English

NSC-300584

Code

English

SC-13504

Code

English

ropizine [INN]

Common Name

English

ROPIZINE [USAN]

Common Name

English

1-(Diphenylmethyl)-4-[[(6-methyl-2-pyridyl)methylene]amino]piperazine

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264