CHLORIDE ION

US Previously Marketed

First marketed in 1921

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Cl
Molecular Weight	35.453
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M

InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8429	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 3.83616E10

PubMed

Title	Date	PubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.	1982 Oct	6218601
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.	1991 Sep	1887894
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.	1996 Feb	8601381
Effect of vitamin E on aspirin-induced gastric mucosal injury in rats.	2000 Mar	10749339
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.	2001 Dec 7	11740957
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.	2001 Jun	11395602
Serum SP-D is a marker of lung injury in rats.	2002 Apr	11880309
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.	2002 Feb	11850527
Effects of chemical and physical agents on viability and infectivity of Encephalitozoon intestinalis determined by cell culture and flow cytometry.	2002 Jun	12019139
Botulinum toxin type A may improve bladder function in a rat chemical cystitis model.	2003 Feb	12599022
Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	2003 Jul	12646421
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.	2004 Apr	15125461
Expression of a 72-kDa heat shock protein, and its cytoprotective function, in gastric mucosa in cirrhotic rats.	2004 Aug	15338365
Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury.	2004 Mar	15090967
Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.	2004 Nov 1	15331673
Esophageal ATP synthase and keratinocyte growth factor gene expression changes after acid and bile-induced mucosal damage.	2005 Apr	15883737
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].	2005 Jun	15970105
Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem.	2005 Sep 14	16162281
[Effects of lateral position and independent lung ventilation on unilateral acute lung injury in dogs].	2006 May	16759491
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.	2006 Oct 20	16945336
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.	2007 Jul-Aug	17627322
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.	2008 Apr 23	18367213
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].	2008 Jun	18549715
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.	2008 Jun	18497604
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.	2009 Jan	18594983
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].	2009 Jun	19957777
Animal study for airway inflammation triggered by gastroesophageal reflux.	2009 Nov 20	19951613
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.	2010 Aug	20872349
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.	2010 Nov	20818264
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.	2010 Nov	20719974

Patents

Name

Type

Language

CHLORIDE ION

Common Name

English

PERCHLORIDE

Common Name

English

CHLORIDE [VANDF]

Common Name

English

CHLORIDE

Systematic Name

English

CHLORIDE ANION

Common Name

English

Chloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68243