CHLORIDE ION

US Previously Marketed

First marketed in 1921

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Cl
Molecular Weight	35.453
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-1

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M

InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8429	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 1971

PubMed

Title	Date	PubMed
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.	1985 Aug	3865005
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.	1991 Sep	1887894
Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents.	1999 Nov	10674923
Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa.	1999 Nov	10564113
Role of tachykinin receptors in the central processing of afferent input from the acid-threatened rat stomach.	2001 Dec 15	11730984
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.	2001 Dec 7	11740957
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.	2001 Jun	11390426
Role of nitric oxide in acidosis-induced intestinal injury in anesthetized rats.	2001 Oct	11574821
Serum SP-D is a marker of lung injury in rats.	2002 Apr	11880309
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.	2002 Feb	11850527
[The change of alveolar fluid clearance in acute lung injury rat].	2002 Jan	11953099
Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage.	2002 Jan 4	11837250
Effects of chemical and physical agents on viability and infectivity of Encephalitozoon intestinalis determined by cell culture and flow cytometry.	2002 Jun	12019139
[Reactive airways dysfunction syndrome (Brooks syndrome)].	2002 Sep 21	12378975
Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat.	2003 Aug	12853844
c-Fos immunoreactivity in the brain after esophageal acid stimulation.	2003 Aug 18	12928072
Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach.	2003 Feb	12588467
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.	2004 Apr	15125461
In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line.	2004 Feb	15046208
Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury.	2004 Mar	15090967
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].	2005 Jun	15970105
Pulmonary aspiration: new therapeutic approaches in the experimental model.	2005 Sep	16129981
Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats.	2006 Dec	17139445
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.	2006 Nov	16984587
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006 Oct	16985189
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.	2006 Oct 20	16945336
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.	2007 Sep 1	17627983
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.	2008 Apr 23	18367213
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.	2008 Aug	18573544
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].	2008 Jun	18549715
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].	2009 Jun	19957777
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.	2009 Mar	19060228
Animal study for airway inflammation triggered by gastroesophageal reflux.	2009 Nov 20	19951613
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.	2010	20380354
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.	2010 Aug	20872349
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.	2010 Nov	20818264
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.	2010 Nov	20719974
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.	2010 Nov 29	21114838
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.	2010 Oct	20719367
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.	2013 Dec 15	24144632

Patents

Name

Type

Language

CHLORIDE ION

Common Name

English

PERCHLORIDE

Common Name

English

CHLORIDE [VANDF]

Common Name

English

CHLORIDE

Systematic Name

English

CHLORIDE ANION

Common Name

English

Chloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C68243