U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Details

Stereochemistry ACHIRAL
Molecular Formula Cl
Molecular Weight 35.453
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of Chloride ion

SMILES

[Cl-]

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI=1S/ClH/h1H/p-1

HIDE SMILES / InChI

Description

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

1921
1468
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

1971
PubMed

PubMed

TitleDatePubMed
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.
1991 Sep
Role of tachykinin receptors in the central processing of afferent input from the acid-threatened rat stomach.
2001 Dec 15
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.
2001 Jun
Bile-induced adenosine triphosphate depletion and mucosal damage during reflux esophagitis.
2001 May
Role of nitric oxide in acidosis-induced intestinal injury in anesthetized rats.
2001 Oct
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.
2002 Aug
c-Fos immunoreactivity in the brain after esophageal acid stimulation.
2003 Aug 18
Botulinum toxin type A may improve bladder function in a rat chemical cystitis model.
2003 Feb
Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia.
2004 Jan
Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
2005
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].
2006 Jun
[Effects of lateral position and independent lung ventilation on unilateral acute lung injury in dogs].
2006 May
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.
2006 Nov
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.
2006 Oct
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.
2007 Sep 1
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.
2008 Jun
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.
2008 Mar
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.
2009 Mar
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010 Aug
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
2010 Nov
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
2010 Oct
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
2010 Sep
Patents

Patents

03931143
18
03931151
3
03931217
11
03931239
40
03932426
35
03932479
113
03932524
68
03932644
2
03933802
2
03933906
2
03934024
2
03936418
3
03937704
32
03940411
10
03940421
2
03940486
2
03943154
10
03946001
3
03947417
2
03947445
3
03947582
13
03948955
2
03950380
3
03950390
2
03950393
3
03950406
119
03950423
2
03951976
2
03951980
4
03953402
2
Name Type Language
CHLORIDE
VANDF   WHO-DD  
Preferred Name English
Chloride ion
Common Name English
PERCHLORIDE
Common Name English
CHLORIDE [VANDF]
Common Name English
CHLORIDE ANION
Common Name English
Chloride [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68243
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LOINC 2075-0
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NCI_THESAURUS C597
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DSLD 37 (Number of products:1261)
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CFR 21 CFR 862.1170
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Code System Code Type Description
EPA CompTox
DTXSID6043969
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PRIMARY
SMS_ID
100000124340
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PRIMARY
EVMPD
SUB32047
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PRIMARY
CHEBI
17996
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PRIMARY
PUBCHEM
312
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PRIMARY
CAS
16887-00-6
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PRIMARY
DRUG BANK
DB14547
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PRIMARY
RXCUI
153974
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PRIMARY RxNorm
NCI_THESAURUS
C1741
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PRIMARY
DAILYMED
Q32ZN48698
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PRIMARY
FDA UNII
Q32ZN48698
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PRIMARY
WIKIPEDIA
Chloride
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PRIMARY
ACTIVE MOIETY
Structure of Chloride ion
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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