BENZODEPA

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H16N3O3P
Molecular Weight	281.2475
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(NP(=O)(N1CC1)N2CC2)OCC3=CC=CC=C3

InChI

InChIKey=VFIUCBTYGKMLCM-UHFFFAOYSA-N

InChI=1S/C12H16N3O3P/c16-12(18-10-11-4-2-1-3-5-11)13-19(17,14-6-7-14)15-8-9-15/h1-5H,6-10H2,(H,13,16,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14201277 | https://www.ncbi.nlm.nih.gov/pubmed/14088841 | https://www.ncbi.nlm.nih.gov/pubmed/14102077 |
Curator's Comment: Note: the Code Name AB-103 is also in use for a peptide drug in development for the treatment of necrotising fasciitis.

Benzodepa is an aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. It has been studied as a potential treatment for a variety of cancers, most notably bronchiogenic carcinoma.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA 278 Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13740023	Crosslinking Agent 81

Conditions

Condition	Modality	Targets	Highest Phase	Product
Inoperable bronchogenic carcinoma 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13740023 https://www.ncbi.nlm.nih.gov/pubmed/14201277	Curative		Not Provided 504	Unknown Approved Use Unknown
Gastrointestinal carcinoma 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14088841	Preventing		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
A STUDY OF BENZCARBIMINE (AB-103; NSC-37096) IN PATIENTS WITH VARIOUS MALIGNANCIES.	1963 Dec	14102077
AB-103 (NSC-37096) IN THE TREATMENT OF BRONCHOGENIC CARCINOMA.	1964 Jul	14201277

Patents

Sample Use Guides

In Vivo Use Guide

In clinical trial against bronchogenic carcinoma, AB-103 was administered intravenously at doses 0.3-6.4 mg/kg.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Name

Type

Language

BENZODEPA

Official Name

English

NSC-37096

Code

English

CARBAMIC ACID, (BIS(1-AZIRIDINYL)PHOSPHINYL)-, PHENYLMETHYL ESTER

Common Name

English

benzodepa [INN]

Common Name

English

BENZODEPA [MI]

Common Name

English

AB-103 (BENZODEPA)

Code

English

Benzyl[bis(1-aziridinyl)phosphinyl]carbamate

Systematic Name

English

BENZODEPA [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C292