SPIRIPROSTIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H34N2O4
Molecular Weight	366.495
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCC[C@H]1CC[C@]2(NC(=O)NC2=O)[C@@H]1CCCCCCC(O)=O

InChI

InChIKey=FFUQYYWTQVXVNM-YRNRMSPPSA-N

InChI=1S/C20H34N2O4/c1-2-3-4-7-10-15-13-14-20(18(25)21-19(26)22-20)16(15)11-8-5-6-9-12-17(23)24/h15-16H,2-14H2,1H3,(H,23,24)(H2,21,22,25,26)/t15-,16+,20-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1686235 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y

Spiriprostil (IBI-P-01028 or R,S-cis-6-(6'-carboxyhexyl)-7-trans-n-hexyl-1,3-diazaspiro-[4-4]-nona n-2,4- dione) is a cytoprotective agent. It is an anti-ulcer agent.

Approval Year

PubMed

Title	Date	PubMed
Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.	1991 Sep-Oct	1686235

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: after a single oral dose of 50 mg/kg, the compound is rapidly adsorbed and reaches a maximum blood concentration after 90 min. Drug accumulation was assessed in dogs given multiple 50 mg/kg doses; this dose showed cytoprotective activities in laboratory animals.

Route of Administration: Oral

Name

Type

Language

SPIRIPROSTIL

Official Name

English

spiriprostil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568