MIDEPLANIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C93H109Cl2N11O32
Molecular Weight	1963.821
Optical Activity	UNSPECIFIED
Defined Stereocenters	23 / 23
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]%14(O[C@]1([H])C2=CC(Cl)=C(OC3=CC4=CC(OC5=CC=C(C[C@@]6([H])NC(=O)[C@H](N)C7=CC(OC8=CC(=CC(O)=C8)[C@]([H])(NC6=O)C(=O)N[C@@]4([H])C(=O)N[C@]9([H])C%10=CC=C(O)C(=C%10)C%11=C(C=C(O)C=C%11O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%12O)[C@@H](NC(=O)[C@@]1([H])NC9=O)C(=O)NCCCN(C)C)=C(O)C=C7)C=C5Cl)=C3O[C@@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%13NC(=O)CCCCCCC(C)C)C=C2)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%14NC(C)=O

InChI

InChIKey=KVZUWEFUEGGULL-XEQFMUSQSA-N

InChI=1S/C93H109Cl2N11O32/c1-38(2)11-8-6-7-9-12-65(115)100-73-79(120)76(117)63(36-108)135-92(73)138-83-60-30-45-31-61(83)132-57-20-16-43(28-52(57)95)82(137-91-72(98-39(3)110)78(119)75(116)62(35-107)134-91)74-90(129)104-71(86(125)97-21-10-22-106(4)5)50-33-47(112)34-59(133-93-81(122)80(121)77(118)64(37-109)136-93)66(50)49-27-42(15-17-54(49)113)68(87(126)105-74)102-89(128)70(45)103-88(127)69-44-25-46(111)32-48(26-44)130-58-29-41(14-18-55(58)114)67(96)85(124)99-53(84(123)101-69)24-40-13-19-56(131-60)51(94)23-40/h13-20,23,25-34,38,53,62-64,67-82,91-93,107-109,111-114,116-122H,6-12,21-22,24,35-37,96H2,1-5H3,(H,97,125)(H,98,110)(H,99,124)(H,100,115)(H,101,123)(H,102,128)(H,103,127)(H,104,129)(H,105,126)/t53-,62-,63-,64-,67-,68-,69+,70-,71-,72-,73-,74+,75-,76-,77-,78-,79-,80+,81+,82-,91+,92+,93+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8444061 | https://adisinsight.springer.com/drugs/800000485

Mideplanin (MDL 62873), a teicoplanin amide derivative, was studied as an antibacterial agent against Gram-positive bacteria. However, further, development appears to have been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Name

Type

Language

MIDEPLANIN

Official Name

English

MIDEPLANIN [USAN]

Common Name

English

mideplanin [INN]

Common Name

English

Ristomycin A aglycone, 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-β-D-glucopyranosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-O-α-D-

Systematic Name

English

A mixture of six substances of which 70% is: 34-((2-acetamido-2-deoxy-beta-D-glucopyranosyl)oxy)-15-amino-22,31-dichloro-56-((2-deoxy-2-(8-methylnonanamido)-beta-D-glucopyranosyl)oxy)-N-(3-(dimethylamino)propyl)-2,3,16,17,18,19,35,36,37,38,48,49,50,50a-t

Common Name

English

Code System Code Type Description

PUBCHEM

16132175