Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H16F3N3O3 |
Molecular Weight | 415.3652 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)OC1=CC=C(C=C1)C2=CC3=C(OCCN(CC4=NC=CC=N4)C3=O)C=C2
InChI
InChIKey=YNUAEEJQYHYLMS-UHFFFAOYSA-N
InChI=1S/C21H16F3N3O3/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19/h1-9,12H,10-11,13H2
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1980 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29017927 |
0.97 µM [IC50] |
Sample Use Guides
Phase 3 clinical trial designed to determine the efficacy, safety, and tolerability of the late sodium current inhibitor eleclazine in shortening the corrected QT (QTcF) interval in subjects with type 3 Long QT Syndrome (LQT3). 41 subjects with genotype-confirmed LQT3 received a 48 mg oral loading dose of eleclazine followed by 12 weeks of treatment with 3 mg oral eleclazine once daily and then 12 weeks of treatment with 6 mg oral eleclazine once daily.
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
FDA ORPHAN DRUG |
446214
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
71183216
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
DE-57
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
SUB179548
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
100000164912
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
1443211-72-0
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
C174857
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
CHEMBL3707392
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
DB12394
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
PUY08529FK
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY | |||
|
9978
Created by
admin on Sat Dec 16 05:03:02 GMT 2023 , Edited by admin on Sat Dec 16 05:03:02 GMT 2023
|
PRIMARY |
ACTIVE MOIETY