U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C9H13N3O2
Molecular Weight 195.2188
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINOMETRADINE

SMILES

C=CCn1c(cc(=O)n(CC)c1=O)N

InChI

InChIKey=NGXUUAFYUCOICP-UHFFFAOYSA-N
InChI=1S/C9H13N3O2/c1-3-5-12-7(10)6-8(13)11(4-2)9(12)14/h3,6H,1,4-5,10H2,2H3

HIDE SMILES / InChI
AMINOMETRADINE, a uracil derivative, is a diuretic. It appears to inhibit the reabsorption of sodium ions by the renal tubules. AMINOMETRADINE is used in the management of edema and in the treatment of congestive heart failure.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Mincard

Approved Use

Diuretic

Launch Date

-5.04921588E11
Doses

Doses

DosePopulationAdverse events​
800 mg 1 times / day multiple, oral (max)
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
unhealthy
n = 22
Health Status: unhealthy
Condition: congestive heart failure
Sex: M+F
Population Size: 22
Sources:
Disc. AE: Nausea, Vomiting...
Other AEs: Diarrhoea, Epigastric pain...
AEs leading to
discontinuation/dose reduction:
Nausea (3 patients)
Vomiting (3 patients)
Other AEs:
Diarrhoea (mild, 1 patient)
Epigastric pain (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Epigastric pain 1 patient
800 mg 1 times / day multiple, oral (max)
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
unhealthy
n = 22
Health Status: unhealthy
Condition: congestive heart failure
Sex: M+F
Population Size: 22
Sources:
Nausea 3 patients
Disc. AE
800 mg 1 times / day multiple, oral (max)
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
unhealthy
n = 22
Health Status: unhealthy
Condition: congestive heart failure
Sex: M+F
Population Size: 22
Sources:
Vomiting 3 patients
Disc. AE
800 mg 1 times / day multiple, oral (max)
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
unhealthy
n = 22
Health Status: unhealthy
Condition: congestive heart failure
Sex: M+F
Population Size: 22
Sources:
Diarrhoea mild, 1 patient
800 mg 1 times / day multiple, oral (max)
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
unhealthy
n = 22
Health Status: unhealthy
Condition: congestive heart failure
Sex: M+F
Population Size: 22
Sources:
PubMed

PubMed

TitleDatePubMed
Therapeutic and toxic effects of enteric-coated aminometramide.
1956 Aug
Current therapeutics. CVIII. Aminometradine.
1956 Dec
Aminometradine in treatment of congestive heart failure.
1956 May 12
AMINOMETRADINE.
1956 Sep 8
Laboratory and clinical observations on three similar diuretic agents: aminophylline, aminometradine (mictine) and aminoisometradine (rolicton).
1957 Dec
Name Type Language
AMINOMETRADINE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
1-ALLYL-6-AMINO-3-ETHYLURACIL
Systematic Name English
AMINOMETRADINE [WHO-DD]
Common Name English
AMINOMETRADINE [MART.]
Common Name English
AMINOMETRADINE [MI]
Common Name English
AMINOMETRADINE [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C448
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
Code System Code Type Description
INN
555
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
WIKIPEDIA
AMINOMETRADINE
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
DRUG CENTRAL
169
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
CAS
642-44-4
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
RXCUI
1440266
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY RxNorm
FDA UNII
PPM8SX5Q3V
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
EVMPD
SUB05441MIG
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
ChEMBL
CHEMBL2104036
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
PUBCHEM
12551
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
EPA CompTox
642-44-4
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
ECHA (EC/EINECS)
211-384-6
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
NCI_THESAURUS
C76645
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY
MERCK INDEX
M1007
Created by admin on Sat Jun 26 07:26:55 UTC 2021 , Edited by admin on Sat Jun 26 07:26:55 UTC 2021
PRIMARY Merck Index