| Stereochemistry | EPIMERIC |
| Molecular Formula | C20H37N3O13 |
| Molecular Weight | 527.5201 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 16 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC4(O[C@]1([H])[C@H](O[C@@]3([H])[C@H](O)[C@@H](N)C[C@@H](NC)[C@@H]3O)O[C@H](CO)[C@@H]2O)O[C@]([H])([C@@H](N)CO)[C@H](O)[C@H](O)[C@H]4O
InChI
InChIKey=GRRNUXAQVGOGFE-SVNOMHMPSA-N
InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8+,9+,10-,11-,12+,13-,14+,15-,16-,17-,18+,19-,20?/m0/s1
Destomycin A is an aminoglycoside antibiotic and is reported to have antibacterial and anthelmintic activity. It has an antibacterial effect on Gram-positive bacteria, Gram-negative bacteria, and fungi. The mode of action of destomycin A is the inhibition of polypeptide synthesis in cells of Escherichia coli and stimulation of adenylate cyclase in several animal tissues. Destomycin A is added to feed for pigs and chickens to prevent parasitic infection of Ascaris suum (the mechanism of action involves inhibition of vitelline coat formation of the parasite eggs.)
Approval Year
PubMed
Patents
Sample Use Guides
The in vitro antitrypanosomal activity of the 10 microbial metabolites was determined using GUTat 3.1 (T. b. brucei) and STIB900 (T. b. rhodesiense). Destomycin A, was the least active compounds against GUTat 3.1 (IC50 = 330 ng/mL) and STIB900 (IC50 = 210 ng/mL) but its IC50 values can still be considered as active.
SUBSTANCE RECORD
