ALADORIAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13NO4S
Molecular Weight	267.301
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C2SCCN(CC2=C1)C(=O)C(O)=O

InChI

InChIKey=FPWBHFYYVSNIFZ-UHFFFAOYSA-N

InChI=1S/C12H13NO4S/c1-17-9-2-3-10-8(6-9)7-13(4-5-18-10)11(14)12(15)16/h2-3,6H,4-5,7H2,1H3,(H,15,16)

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800034371 | http://www.armgo.com/pipeline.html

ARMGO and Servier are developing an anti-arrhythmia drug aladorian (ARM036) for the treatment of heart failure, arrhythmia and ventricular tachycardia. Aladorian was the first in-house discovered, novel, small molecule NCE (Rycal®) from ARMGO’s library that was advanced into clinical studies. ARM036 completed multiple Phase IIa clinical studies in chronic heart failure patients, demonstrating positive activity and safety in patients, and validating ARMGO’s approach for drug discovery and candidate selection on the RyR target.

Originator

Approval Year

PubMed

Title	Date	PubMed
Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls.	2014 Dec	24906629

Patents

Sample Use Guides

In Vivo Use Guide

Rats: 1.11 mg/kg/day ARM036 given via osmotic pump

Route of Administration: Oral

Name

Type

Language

ALADORIAN

Official Name

English

S-441211

Code

English

aladorian [INN]

Common Name

English

ARM036

Code

English

Aladorian [WHO-DD]

Common Name

English

S36

Code

English

S44121-1

Code

English

(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)oxoacetic acid

Systematic Name

English

ARM-036

Code

English

ALADORIAN [USAN]

Common Name

English

S-44121-1

Code

English

S-36

Code

English

Code System Code Type Description

FDA UNII

PJ5KSA836G