Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C44H62N2O12 |
Molecular Weight | 810.9693 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 11 / 11 |
E/Z Centers | 7 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@H](C(=O)NC\C=C\C=C(/C)[C@@H](OC)[C@@H](C)[C@@H]1O[C@H](\C=C\C=C\C=C(/C)C(=O)C2=C(O)C=CN(C)C2=O)[C@H](O)[C@@H]1O)[C@@]3(O)O[C@@H](\C=C\C=C/C)C(C)(C)[C@@H](O)[C@H]3O
InChI
InChIKey=NTAHMPNXQOYXSX-WKSONYIQSA-N
InChI=1S/C44H62N2O12/c1-10-12-14-22-32-43(6,7)39(51)40(52)44(55,58-32)29(11-2)41(53)45-24-18-17-20-27(4)37(56-9)28(5)38-36(50)35(49)31(57-38)21-16-13-15-19-26(3)34(48)33-30(47)23-25-46(8)42(33)54/h10,12-23,25,28-29,31-32,35-40,47,49-52,55H,11,24H2,1-9H3,(H,45,53)/b12-10-,15-13+,18-17+,21-16+,22-14+,26-19+,27-20+/t28-,29-,31-,32+,35+,36+,37-,38+,39+,40-,44-/m1/s1
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21139624
https://www.ncbi.nlm.nih.gov/pubmed/11278992
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21139624
https://www.ncbi.nlm.nih.gov/pubmed/11278992
Aurodox is an antibiotic obtained from a streptomyces variant considered as possibly effective against streptococcus pyogenes infections. It may promote growth in poultry. Aurodox inhibits protein biosynthesis by binding to elongation factor Tu (EF-Tu). Aurodox has being shown to possess the ability to inhibit the secretion of type III-secreted proteins without affecting bacterial growth.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0030254 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21139624 |
|||
Target ID: P60339 Gene ID: 3168327.0 Gene Symbol: tufB Target Organism: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21139624
oral administration of aurodox, 25 or 100 mg/kg
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21139624
Aurodox strongly inhibited T3SS-mediated hemolysis with an IC(50) value of 1.5 ug/ml without affecting bacterial growth in liquid media.
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
135509117
Created by
admin on Sat Dec 16 09:26:44 GMT 2023 , Edited by admin on Sat Dec 16 09:26:44 GMT 2023
|
PRIMARY | |||
|
DB04124
Created by
admin on Sat Dec 16 09:26:43 GMT 2023 , Edited by admin on Sat Dec 16 09:26:43 GMT 2023
|
PRIMARY | |||
|
m2143
Created by
admin on Sat Dec 16 09:26:44 GMT 2023 , Edited by admin on Sat Dec 16 09:26:44 GMT 2023
|
PRIMARY | Merck Index | ||
|
PGP5RZH64G
Created by
admin on Sat Dec 16 09:26:44 GMT 2023 , Edited by admin on Sat Dec 16 09:26:44 GMT 2023
|
PRIMARY | |||
|
DTXSID801043992
Created by
admin on Sat Dec 16 09:26:44 GMT 2023 , Edited by admin on Sat Dec 16 09:26:44 GMT 2023
|
PRIMARY | |||
|
12704-90-4
Created by
admin on Sat Dec 16 09:26:43 GMT 2023 , Edited by admin on Sat Dec 16 09:26:43 GMT 2023
|
PRIMARY | |||
|
233989
Created by
admin on Sat Dec 16 09:26:44 GMT 2023 , Edited by admin on Sat Dec 16 09:26:44 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)