U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3H8O3
Molecular Weight 92.0939
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERIN

SMILES

C(C(CO)O)O

InChI

InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

HIDE SMILES / InChI
Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DERM-APPLY

Approved Use

Restore moisture balance in dry skin or hair.

Launch Date

5.9952962E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1770 mg/L
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.895 h
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
39.3 min
120 mmol/m² single, intravenous
dose: 120 mmol/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Other AEs: Agitation, Groaning...
Other AEs:
Agitation (1 patient)
Groaning (1 patient)
Speech loss (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Agitation 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Groaning 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Speech loss 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver.
1999 Feb
Calcitriol directly sensitizes renal tubular cells to ATP-depletion- and iron-mediated attack.
1999 Jun
Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum.
1999 May
Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases.
1999 Oct
Differential expression of renal adenosine A(1) receptors induced by acute renal failure.
2000 Mar 15
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
2001
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions.
2001
Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility.
2001 Feb
Catalase has a novel protective role against electrophile killing of Xanthomonas.
2001 Feb
Circadian regulation of phospholipid metabolism in retinal photoreceptors and ganglion cells.
2001 Feb
Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes.
2001 Feb
Correlation of the electrical and intrinsic optical signals in the chicken spreading depression phenomenon.
2001 Feb 16
Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes.
2001 Feb 2
Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance.
2001 Feb 23
Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates.
2001 Feb 26
Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis.
2001 Jan
Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers.
2001 Jan
L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same?
2001 Jan
Spontaneous otoacoustic emissions in humans with endolymphatic hydrops.
2001 Jan
Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops.
2001 Jan
Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films.
2001 Jan
Identification of amino acids in wines by one- and two-dimensional nuclear magnetic resonance spectroscopy.
2001 Jan
Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior.
2001 Jan
Role of botrytized grape micro-organisms in SO2 binding phenomena.
2001 Jan
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae.
2001 Jan
Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora.
2001 Jan
Molecular oxygen spin-lattice relaxation in solutions measured by proton magnetic relaxation dispersion.
2001 Jan
Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family.
2001 Jan 26
Characteristics and glycerol metabolism of fumarate-reducing Enterococcus faecalis RKY1.
2001 Jan 5
Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source.
2001 Jan 5
Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3.
2001 Jan 5
Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases.
2001 Jan 5
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
2001 Jan-Feb
Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata).
2001 Mar
Production of ethanol and xylitol from corn cobs by yeasts.
2001 Mar
Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates.
2001 Mar 1
Name Type Language
GLYCERIN
FCC   HSDB   II   INCI   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
PZN 7474853
Code English
GLYCERIN,ANHYDROUS
VANDF  
Common Name English
GLYCEROL [INN]
Common Name English
GLYCEROL [EP]
Common Name English
GLYCERIN [ORANGE BOOK]
Common Name English
GLYCEROL 85% [WHO-DD]
Common Name English
1,2,3-PROPANETRIOL
Systematic Name English
GLYCEROL
EP   FHFI   INN   MART.   MI   WHO-DD   WHO-IP  
INN  
Official Name English
GLYCERIN [II]
Common Name English
GLYCERIN [USP]
Common Name English
GLYCERINUM
HPUS  
Common Name English
2-PROPANOL, 1,3-DIHYDROXY-
Systematic Name English
E-422
Code English
1,2,3-TRIHYDROXYPROPANE
Systematic Name English
GLYCERINE
Systematic Name English
GLYCEROLUM [WHO-IP LATIN]
Common Name English
TRYHYDROXYPROPANE
Common Name English
GLYCERIN,ANHYDROUS [VANDF]
Common Name English
GLYCEROL [EP MONOGRAPH]
Common Name English
INS-422
Code English
GLYCERIN [USP-RS]
Common Name English
GLYCEROL [WHO-DD]
Common Name English
NSC-9230
Code English
MONOCTANOIN COMPONENT D
Common Name English
GLYCERIN [HSDB]
Common Name English
GLYCEROL [FHFI]
Common Name English
M 314429
Code English
GLYCERIN [INCI]
Common Name English
GLYCERINUM [HPUS]
Common Name English
FEMA NO. 2525
Code English
GLYCEROL [WHO-IP]
Common Name English
GLYCEROL [MART.]
Common Name English
INS NO.422
Code English
GLYCEROL [MI]
Common Name English
GLYCERIN [VANDF]
Common Name English
Classification Tree Code System Code
LOINC 54283-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
FDA ORPHAN DRUG 28188
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 45300-1
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA16QA03
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54285-2
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2388-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2387-9
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
DSLD 1110 (Number of products:309)
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 349.12
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54284-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NCI_THESAURUS C29697
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NDF-RT N0000185370
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
EPA PESTICIDE CODE 63507
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 347.10
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 47632-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
Code System Code Type Description
EPA CompTox
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG BANK
DB09462
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
USP_CATALOG
1295607
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY USP-RS
NDF-RT
N0000006566
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Glycerol [Chemical/Ingredient]
WIKIPEDIA
GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB07948MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB13992MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Allergens [Chemical/Ingredient]
PUBCHEM
753
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYCERIN
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance.
FDA UNII
PDC6A3C0OX
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
CAS
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ChEMBL
CHEMBL692
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NCI_THESAURUS
C29077
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Cell-mediated Immunity [PE]
JECFA MONOGRAPH
INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-289-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG CENTRAL
1316
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
MERCK INDEX
M5790
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Merck Index
INN
444
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased Histamine Release [PE]
RXCUI
4910
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY RxNorm
MESH
D005990
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000185001
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased IgG Production [PE]
HSDB
492
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY