U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3H8O3
Molecular Weight 92.0939
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERIN

SMILES

C(C(CO)O)O

InChI

InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

HIDE SMILES / InChI
Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DERM-APPLY

Approved Use

Restore moisture balance in dry skin or hair.

Launch Date

5.9952962E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1770 mg/L
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
0.895 h
1.2 g/kg single, oral
dose: 1.2 g/kg
route of administration: Oral
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
39.3 min
120 mmol/m² single, intravenous
dose: 120 mmol/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
GLYCERIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Other AEs: Agitation, Groaning...
Other AEs:
Agitation (1 patient)
Groaning (1 patient)
Speech loss (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Agitation 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Groaning 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Speech loss 1 patient
310 g single, oral (total)
Overdose
Dose: 310 g
Route: oral
Route: single
Dose: 310 g
Sources:
unhealthy, 72 years
n = 1
Health Status: unhealthy
Age Group: 72 years
Sex: M
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.
2001
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress.
2001
Reversible vacuolation of T-tubules in skeletal muscle: mechanisms and implications for cell biology.
2001
A comparison of F-actin labeling methods for light microscopy in different plant specimens: multiple techniques supplement each other.
2001 Aug
Potential of freezing in wastewater treatment: soluble pollutant applications.
2001 Feb
Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes.
2001 Feb
Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up.
2001 Feb
Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe.
2001 Feb
Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b.
2001 Feb
How water molecules pass through aquaporins.
2001 Feb
Structure, location, and lipid perturbations of melittin at the membrane interface.
2001 Feb
Changes in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2 enzyme: a molecular dynamics simulation study.
2001 Feb
Catalase has a novel protective role against electrophile killing of Xanthomonas.
2001 Feb
Circadian regulation of phospholipid metabolism in retinal photoreceptors and ganglion cells.
2001 Feb
Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes.
2001 Feb
Correlation of the electrical and intrinsic optical signals in the chicken spreading depression phenomenon.
2001 Feb 16
Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes.
2001 Feb 2
The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress.
2001 Feb 2
Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance.
2001 Feb 23
Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates.
2001 Feb 26
Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis.
2001 Jan
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus.
2001 Jan
Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes.
2001 Jan
[Life style-related disease].
2001 Jan
Spontaneous otoacoustic emissions in humans with endolymphatic hydrops.
2001 Jan
The innervation of the triangular fibrocartilage complex: nitric acid maceration rediscovered.
2001 Jan
The thermic effect is greater for structured medium- and long-chain triacylglycerols versus long-chain triacylglycerols in healthy young women.
2001 Jan
Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films.
2001 Jan
Identification of amino acids in wines by one- and two-dimensional nuclear magnetic resonance spectroscopy.
2001 Jan
Nod factor-induced phosphatidic acid and diacylglycerol pyrophosphate formation: a role for phospholipase C and D in root hair deformation.
2001 Jan
Role of botrytized grape micro-organisms in SO2 binding phenomena.
2001 Jan
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae.
2001 Jan
Efficient lentiviral transduction of primary human acute myelogenous and lymphoblastic leukemia cells.
2001 Jan
Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs.
2001 Jan
Purification, crystallization and quaternary structure analysis of a glycerol dehydrogenase S305C mutant from Bacillus stearothermophilus.
2001 Jan
Short-term 17beta-estradiol decreases glucose R(a) but not whole body metabolism during endurance exercise.
2001 Jan
Physical exercise and normobaric hypoxia: independent modulators of peripheral cholecystokinin metabolism in man.
2001 Jan
Molecular oxygen spin-lattice relaxation in solutions measured by proton magnetic relaxation dispersion.
2001 Jan
Leavening ability of baker's yeast exposed to hyperosmotic media.
2001 Jan 15
Characterization of lyso-galactolipids, C-2 and C-3 O-acyl trigalactosylglycerol isomers, obtained from the lichenized fungus Dictyonema glabratum.
2001 Jan 15
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.
2001 Jan 16
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats.
2001 Jan 26
Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes.
2001 Jan 30
Characteristics and glycerol metabolism of fumarate-reducing Enterococcus faecalis RKY1.
2001 Jan 5
Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source.
2001 Jan 5
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
2001 Jan-Feb
In-vitro growth of murine pre-antral follicles after isolation from cryopreserved ovarian tissue.
2001 Mar
Effects of food texture change on metabolic parameters: short- and long-term feeding patterns and body weight.
2001 Mar
Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production.
2001 Mar
Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates.
2001 Mar 1
Name Type Language
GLYCERIN
FCC   HSDB   II   INCI   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
PZN 7474853
Code English
GLYCERIN,ANHYDROUS
VANDF  
Common Name English
GLYCEROL [INN]
Common Name English
GLYCEROL [EP]
Common Name English
GLYCERIN [ORANGE BOOK]
Common Name English
GLYCEROL 85% [WHO-DD]
Common Name English
1,2,3-PROPANETRIOL
Systematic Name English
GLYCEROL
EP   FHFI   INN   MART.   MI   WHO-DD   WHO-IP  
INN  
Official Name English
GLYCERIN [II]
Common Name English
GLYCERIN [USP]
Common Name English
GLYCERINUM
HPUS  
Common Name English
2-PROPANOL, 1,3-DIHYDROXY-
Systematic Name English
E-422
Code English
1,2,3-TRIHYDROXYPROPANE
Systematic Name English
GLYCERINE
Systematic Name English
GLYCEROLUM [WHO-IP LATIN]
Common Name English
TRYHYDROXYPROPANE
Common Name English
GLYCERIN,ANHYDROUS [VANDF]
Common Name English
GLYCEROL [EP MONOGRAPH]
Common Name English
INS-422
Code English
GLYCERIN [USP-RS]
Common Name English
GLYCEROL [WHO-DD]
Common Name English
NSC-9230
Code English
MONOCTANOIN COMPONENT D
Common Name English
GLYCERIN [HSDB]
Common Name English
GLYCEROL [FHFI]
Common Name English
M 314429
Code English
GLYCERIN [INCI]
Common Name English
GLYCERINUM [HPUS]
Common Name English
FEMA NO. 2525
Code English
GLYCEROL [WHO-IP]
Common Name English
GLYCEROL [MART.]
Common Name English
INS NO.422
Code English
GLYCEROL [MI]
Common Name English
GLYCERIN [VANDF]
Common Name English
Classification Tree Code System Code
LOINC 54283-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
FDA ORPHAN DRUG 28188
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
JECFA EVALUATION INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 45300-1
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA16QA03
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54285-2
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2388-7
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 2387-9
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
DSLD 1110 (Number of products:309)
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 349.12
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-ATC A06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 54284-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NCI_THESAURUS C29697
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AG04
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
NDF-RT N0000185370
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
EPA PESTICIDE CODE 63507
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
WHO-VATC QA06AX01
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
CFR 21 CFR 347.10
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
LOINC 47632-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
Code System Code Type Description
EPA CompTox
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG BANK
DB09462
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
USP_CATALOG
1295607
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY USP-RS
NDF-RT
N0000006566
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Glycerol [Chemical/Ingredient]
WIKIPEDIA
GLYCEROL
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB07948MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
EVMPD
SUB13992MIG
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Allergens [Chemical/Ingredient]
PUBCHEM
753
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
GLYCERIN
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance.
FDA UNII
PDC6A3C0OX
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
CAS
56-81-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ChEMBL
CHEMBL692
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NCI_THESAURUS
C29077
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Cell-mediated Immunity [PE]
JECFA MONOGRAPH
INS-422
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-289-5
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
DRUG CENTRAL
1316
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
MERCK INDEX
M5790
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Merck Index
INN
444
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased Histamine Release [PE]
RXCUI
4910
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY RxNorm
MESH
D005990
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY
NDF-RT
N0000185001
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY Increased IgG Production [PE]
HSDB
492
Created by admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
PRIMARY