Details
Stereochemistry | ACHIRAL |
Molecular Formula | C3H8O3 |
Molecular Weight | 92.0939 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(C(CO)O)O
InChI
InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
Glycerin (glycerol) is 3-carbon alcohol naturally occurring in the human body. It is the structural backbone triacylglycerol molecules, and can also be converted to a glycolytic substrate for subsequent metabolism. Glycerin is a colorless, odorless, viscous, sweet-tasting liquid. The FDA classifies glycerol as "generally recognized as safe". Glycerin is used in the pharmaceutical industry as a sweetener in syrups, lozenges, and as an excipient in eyewash solutions. As an individual prescription product, glycerin has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer. Glycerin has many other uses in the agricultural, food and pharmaceutical industry.
Approval Year
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1770 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.895 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8369006/ |
1.2 g/kg single, oral dose: 1.2 g/kg route of administration: Oral experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
39.3 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/4300572/ |
120 mmol/m² single, intravenous dose: 120 mmol/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
GLYCERIN serum | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Other AEs: Agitation, Groaning... Other AEs: Agitation (1 patient) Sources: Groaning (1 patient) Speech loss (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Agitation | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Groaning | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Speech loss | 1 patient | 310 g single, oral (total) Overdose |
unhealthy, 72 years n = 1 Health Status: unhealthy Age Group: 72 years Sex: M Population Size: 1 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
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OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
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Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
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Sources: https://pubmed.ncbi.nlm.nih.gov/9113273/ |
yes |
PubMed
Title | Date | PubMed |
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Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver. | 1999 Feb |
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Calcitriol directly sensitizes renal tubular cells to ATP-depletion- and iron-mediated attack. | 1999 Jun |
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Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum. | 1999 May |
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Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases. | 1999 Oct |
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Differential expression of renal adenosine A(1) receptors induced by acute renal failure. | 2000 Mar 15 |
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Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. | 2001 |
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Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. | 2001 |
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Characterization of northern pintail (Anas acuta) ejaculate and the effect of sperm preservation on fertility. | 2001 Feb |
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Catalase has a novel protective role against electrophile killing of Xanthomonas. | 2001 Feb |
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Circadian regulation of phospholipid metabolism in retinal photoreceptors and ganglion cells. | 2001 Feb |
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Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. | 2001 Feb |
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Correlation of the electrical and intrinsic optical signals in the chicken spreading depression phenomenon. | 2001 Feb 16 |
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Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes. | 2001 Feb 2 |
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Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance. | 2001 Feb 23 |
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Rapid screening of H(2)O(2) production by Mycoplasma mycoides and differentiation of European subsp. mycoides SC (small colony) isolates. | 2001 Feb 26 |
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Biochemical characterization of Mycoplasma bovirhinis, Mycoplasma dispar and recent bovine isolates of Mycoplasma canis. | 2001 Jan |
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Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers. | 2001 Jan |
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L-glutamate efflux with Corynebacterium glutamicum: why is penicillin treatment or Tween addition doing the same? | 2001 Jan |
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Spontaneous otoacoustic emissions in humans with endolymphatic hydrops. | 2001 Jan |
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Distortion-product otoacoustic emissions and glycerol testing in endolymphatic hydrops. | 2001 Jan |
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Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films. | 2001 Jan |
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Identification of amino acids in wines by one- and two-dimensional nuclear magnetic resonance spectroscopy. | 2001 Jan |
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Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior. | 2001 Jan |
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Role of botrytized grape micro-organisms in SO2 binding phenomena. | 2001 Jan |
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Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae. | 2001 Jan |
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Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora. | 2001 Jan |
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Molecular oxygen spin-lattice relaxation in solutions measured by proton magnetic relaxation dispersion. | 2001 Jan |
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Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. | 2001 Jan 26 |
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Characteristics and glycerol metabolism of fumarate-reducing Enterococcus faecalis RKY1. | 2001 Jan 5 |
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Succinic acid production with reduced by-product formation in the fermentation of Anaerobiospirillum succiniciproducens using glycerol as a carbon source. | 2001 Jan 5 |
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Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. | 2001 Jan 5 |
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Nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases. | 2001 Jan 5 |
|
Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection. | 2001 Jan-Feb |
|
Crystallization and preliminary X-ray analysis of the glycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata). | 2001 Mar |
|
Production of ethanol and xylitol from corn cobs by yeasts. | 2001 Mar |
|
Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates. | 2001 Mar 1 |
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Classification Tree | Code System | Code | ||
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LOINC |
54283-7
Created by
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FDA ORPHAN DRUG |
28188
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JECFA EVALUATION |
GLYCEROL
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JECFA EVALUATION |
INS-422
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CODEX ALIMENTARIUS (GSFA) |
INS-422
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LOINC |
45300-1
Created by
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WHO-VATC |
QA16QA03
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LOINC |
54285-2
Created by
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LOINC |
2388-7
Created by
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LOINC |
2387-9
Created by
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DSLD |
1110 (Number of products:309)
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WHO-ATC |
A06AG04
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CFR |
21 CFR 349.12
Created by
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WHO-ATC |
A06AX01
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LOINC |
54284-5
Created by
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NCI_THESAURUS |
C29697
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WHO-VATC |
QA06AG04
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NDF-RT |
N0000185370
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EPA PESTICIDE CODE |
63507
Created by
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WHO-VATC |
QA06AX01
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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CFR |
21 CFR 347.10
Created by
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LOINC |
47632-5
Created by
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Code System | Code | Type | Description | ||
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56-81-5
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PRIMARY | |||
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DB09462
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PRIMARY | |||
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1295607
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PRIMARY | USP-RS | ||
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N0000006566
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | Glycerol [Chemical/Ingredient] | ||
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GLYCEROL
Created by
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PRIMARY | |||
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SUB07948MIG
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PRIMARY | |||
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SUB13992MIG
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PRIMARY | |||
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] | ||
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753
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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GLYCERIN
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | Description: A clear, colourless or almost colourless, syrupy liquid; odourless. Miscibility: Miscible with water and ethanol (~750 g/l) TS; slightly miscible with acetone R; practically immiscible with ether R. Category: Solvent; humectant.Storage: Glycerol should be kept in a tightly closed container. Additional information: Glycerol is hygroscopic. Requirement: Glycerol contains not less than 95.0% and not more than the equivalent of 101.0% of C3H8O3, calculated with reference to theanhydrous substance. | ||
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PDC6A3C0OX
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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56-81-5
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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CHEMBL692
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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C29077
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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N0000184306
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | Cell-mediated Immunity [PE] | ||
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INS-422
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admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | |||
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200-289-5
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PRIMARY | |||
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1316
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PRIMARY | |||
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M5790
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PRIMARY | Merck Index | ||
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444
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PRIMARY | |||
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N0000175629
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | Increased Histamine Release [PE] | ||
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4910
Created by
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PRIMARY | RxNorm | ||
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D005990
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PRIMARY | |||
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N0000185001
Created by
admin on Fri Jun 25 21:13:29 UTC 2021 , Edited by admin on Fri Jun 25 21:13:29 UTC 2021
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PRIMARY | Increased IgG Production [PE] | ||
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492
Created by
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)